Back to Search
Start Over
The 28-Day Mortality Outcome of the Complete Hour-1 Sepsis Bundle in the Emergency Department
- Source :
- Shock (Augusta, Ga.)
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Introduction: The Surviving Sepsis Campaign published the Hour-1 Sepsis Bundle in 2018. The first-hour management of patients with sepsis in the emergency department (ED) is important, as suggested in the Hour-1 Sepsis Bundle. The objectives of the present study were to evaluate 28-day mortality and delayed septic shock with use of a complete and incomplete Hour-1 Sepsis Bundle in the ED. Methods: This prospective cohort study included adult patients with sepsis from March to July 2019. We followed the sepsis protocol used in the ED of a tertiary care hospital. Results: We enrolled 593 patients, with 55.9% in the complete Hour-1 Sepsis Bundle group. The 28-day mortality was 3.9% overall and no significant difference between the complete and incomplete Hour-1 Sepsis Bundle groups (3.6% vs. 4.2%, P = 0.707). Complete Hour-1 Sepsis Bundle treatment was not associated with 28-day mortality (adjusted OR = 2.04, 95% confidence interval [CI] = 0.72–5.74, P = 0.176) or delayed septic shock (adjusted OR = 0.74, 95% CI = 0.30–1.78, P = 0.499). Completion of each bundle did not affect outcomes of 28-day mortality and delayed septic shock. Conclusions: The complete Hour-1 Sepsis Bundle treatment in the ED was not significantly associated with 28-day mortality and delayed septic shock. Trial registration: The trial was registered in the Thai Clinical Trial Registry, TCTR 20200526013.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Surviving Sepsis Campaign
emergency department
Sepsis bundle
Critical Care and Intensive Care Medicine
Clinical Science Aspects
Cohort Studies
Sepsis
Sequential Organ Failure Assessment
qSOFA
antibiotic
Internal medicine
medicine
SOFA
Humans
Prospective Studies
Prospective cohort study
Aged
Aged, 80 and over
ATB
Septic shock
business.industry
quick Sequential Organ Failure Assessment
28-Day mortality
Emergency Physician
Emergency department
Middle Aged
medicine.disease
ED
Shock, Septic
Confidence interval
Clinical trial
EP
hour-1 sepsis bundle
Emergency Medicine
septic shock
Female
Emergency Service, Hospital
business
Patient Care Bundles
Subjects
Details
- ISSN :
- 15400514 and 10732322
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Shock
- Accession number :
- edsair.doi.dedup.....0ab1f679f92933228e9b285eb6cd207e