Back to Search
Start Over
Stage is a better prognostic indicator than morphologic subtype in primary noncutaneous T-cell lymphoma
- Source :
- American journal of clinical pathology. 93(1)
- Publication Year :
- 1990
-
Abstract
- The authors reviewed 28 primary noncutaneous T-cell lymphomas, referred to the Comprehensive Cancer Center Amsterdam, using the updated Kiel classification. Clinical course was related with stage of disease, morphologic subtype, and immunophenotype of the tumor cells. The incidence of primary noncutaneous T-cell lymphomas was 4.1 cases per 1,000,000 people per year. Morphologic classification was difficult and arbitrary, lmmunohistochemistry contributed considerably in diagnosis of this group of tumors. All primary noncutaneous T-cell lymphomas had a poor prognosis, with no significant difference between predominantly small cell (low-grade) and large cell (high-grade) tumors. The only parameter significantly correlating with survival was the stage of the disease at presentation. The results suggest that all types of primary noncutaneous T-cell lymphoma are to be considered high grade and that primary localization (cutaneous vs. noncutaneous) and stage of disease at presentation appear to be more important as predictors of clinical outcome than morphologic or immunophenotypic subtype.
- Subjects :
- Adult
Antigens, Differentiation, T-Lymphocyte
Male
Pathology
medicine.medical_specialty
Cytoplasm
Adolescent
Lymphoma
T-Lymphocytes
Mitosis
Disease
Diagnosis, Differential
Immunoenzyme Techniques
Immunophenotyping
Antigens, CD
Biomarkers, Tumor
Medicine
T-cell lymphoma
Humans
Stage (cooking)
Aged
Neoplasm Staging
Cell Nucleus
business.industry
Histocytochemistry
Incidence (epidemiology)
Large cell
Cancer
General Medicine
Middle Aged
medicine.disease
Prognosis
Survival Rate
Child, Preschool
Female
business
Subjects
Details
- ISSN :
- 00029173
- Volume :
- 93
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- American journal of clinical pathology
- Accession number :
- edsair.doi.dedup.....0aa91287a4330c8ffe559daf91fb34b4