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Drug-coated balloons in treatment of in-stent restenosis: a meta-analysis of randomised controlled trials
- Source :
- Clinical Research in Cardiology
- Publication Year :
- 2012
- Publisher :
- Springer-Verlag, 2012.
-
Abstract
- Background Drug-coated balloons (DCBs) have been developed for the percutaneous treatment of coronary artery disease. An initial focus has been the management of in-stent restenosis (ISR) but randomised controlled trials (RCTs) have been small and powered only for angiographic endpoints. Objective The aim of the work was to assess the clinical and angiographic outcomes of patients treated for ISR with DCB versus control (balloon angioplasty or drug-eluting stents) by a meta-analysis of RCTs. Methods A comprehensive search was performed of RCTs where patients with ISR were randomly assigned to either DCB or alternative coronary intervention. Outcome measurements were death, myocardial infarction (MI), target lesion revascularisation (TLR), binary definition of restenosis and in-lesion late luminal loss (LLL). Results Four studies were identified that fulfilled the inclusion criteria. Pooled odds ratios (ORs) were calculated for patients treated for ISR (n = 399). Mean follow-up duration was 14.5 months. DCBs were associated with lower rates of TLR [8.8 vs. 29.7 % OR (95 % confidence interval, CI) 0.20 (0.11–0.36), p
- Subjects :
- medicine.medical_specialty
Drug coated balloon
Percutaneous
medicine.medical_treatment
Coronary Artery Disease
Balloon
Coronary artery disease
law.invention
Coronary Restenosis
Restenosis
Randomized controlled trial
law
Internal medicine
Angioplasty
Outcome Assessment, Health Care
medicine
Humans
Angioplasty, Balloon, Coronary
Drug-eluting stents
Randomized Controlled Trials as Topic
Original Paper
Drug-coated balloons
business.industry
Drug-Eluting Stents
General Medicine
medicine.disease
Surgery
Meta-analysis
Cardiology
Randomized controlled trials
Radiology
business
Cardiology and Cardiovascular Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 18610692 and 18610684
- Volume :
- 102
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Clinical Research in Cardiology
- Accession number :
- edsair.doi.dedup.....0aa51f66d844a93be824ab2d2e7ee08a