Back to Search
Start Over
The Interleukin-11 Receptor α as a Candidate Ligand-Directed Target in Osteosarcoma: Consistent Data from Cell Lines, Orthotopic Models, and Human Tumor Samples
- Source :
- Cancer Research. 69:1995-1999
- Publication Year :
- 2009
- Publisher :
- American Association for Cancer Research (AACR), 2009.
-
Abstract
- The interleukin-11 receptor α (IL-11Rα) is a functional target in bone metastasis. However, its role in primary bone tumors has not been established. As such, here, we evaluated IL-11Rα as a candidate target in primary and metastatic human osteosarcoma. First, in an orthotopic mouse model, we showed that IL-11Rα protein is markedly expressed in primary osseus and pulmonary metastatic osteosarcoma but absent from control normal tibia and lung. Moreover, systemic administration of an IL-11Rα–targeting phage displaying the cyclic nonapeptide CGRRAGGSC resulted in strong and selective accumulation of IL-11Rα–homing phage particles in the osteosarcoma but not in several control organs. Finally, IL-11Rα expression in a large panel of human primary and metastatic osteosarcoma samples was remarkably consistent with the observations in the orthotopic mouse model. These data establish IL-11Rα as a candidate target in human osteosarcoma and provide leads for the development of novel imaging and therapeutic agents for the management of this malignant tumor. [Cancer Res 2009;69(5):1995–9]
- Subjects :
- Male
musculoskeletal diseases
Cancer Research
Pathology
medicine.medical_specialty
Lung Neoplasms
medicine.medical_treatment
Bone Neoplasms
Ligands
Mice
Cell Line, Tumor
medicine
Animals
Humans
Interleukin-11 Receptor alpha Subunit
Receptor
Osteosarcoma
business.industry
Bone metastasis
Cancer
medicine.disease
Cytokine
Primary bone
Oncology
Systemic administration
Sarcoma
business
Subjects
Details
- ISSN :
- 15387445 and 00085472
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Cancer Research
- Accession number :
- edsair.doi.dedup.....0a9c0bf3bceab7cbf9e1270f4034ffe0