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TNFα expression of subcutaneous adipose tissue in obese and morbid obese females: relationship to adipocyte LPL activity and leptin synthesis
- Source :
- International Journal of Obesity. 26:652-658
- Publication Year :
- 2002
- Publisher :
- Springer Science and Business Media LLC, 2002.
-
Abstract
- Tumor necrosis factor (TNFalpha) has been invoked as an adipostat. Accordingly, the adipose tissue expression of TNFalpha has been shown to be proportional to the degree of adiposity. The regulatory role of TNFalpha in obesity may be controlled by several mechanisms. These include the inhibitory effect on LPL activity, the mediation on glucose homeostasis or the effect on leptin. To assess the role of TNFalpha in obesity we measured adipocyte TNFalpha expression in 96 females with a wide range of adiposity and with or without type 2 diabetes. We analysed the relationship between TNFalpha expression, adipocyte LPL activity, insulin resistance and leptin in this population.The TNFalpha and leptin expression of the adipose tissue in obese and morbid obese patients were significantly higher than in controls. Obese and morbid obese patients had slightly higher levels of LPL activity, but these differences were not significant. We observed a significant relationship between adipose TNFalpha expression and body mass index (r=0.35, P0.001). TNFalpha expression was negatively related to LPL activity (r=-0.28, P0.05) and positively related to leptin expression (r=0.35, P0.001).Our results indicate that obese women, even those with morbid obesity, over-express TNFalpha in subcutaneous adipose tissue in proportion to the magnitude of the fat depot and independently of the presence of type 2 diabetes. The TNFalpha system may be a homeostatic mechanism that prevents further fat deposition by regulating LPL activity and leptin production.
- Subjects :
- Adult
Leptin
medicine.medical_specialty
Adolescent
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Cholesterol, VLDL
Population
Gene Expression
Medicine (miscellaneous)
Adipose tissue
Type 2 diabetes
chemistry.chemical_compound
Insulin resistance
Internal medicine
Adipocyte
Adipocytes
Diabetes Mellitus
medicine
Humans
Insulin
Glucose homeostasis
Obesity
RNA, Messenger
education
Triglycerides
Aged
education.field_of_study
Nutrition and Dietetics
Tumor Necrosis Factor-alpha
business.industry
Cholesterol, HDL
Cholesterol, LDL
Middle Aged
medicine.disease
Obesity, Morbid
Lipoprotein Lipase
Cholesterol
Endocrinology
Adipose Tissue
Diabetes Mellitus, Type 2
chemistry
Female
Insulin Resistance
business
Subjects
Details
- ISSN :
- 14765497 and 03070565
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- International Journal of Obesity
- Accession number :
- edsair.doi.dedup.....0a97ce410277993c7f6447ef64ca5b72