Additional file 1 of Crohn disease-like enterocolitis remission after empagliflozin treatment in a child with glycogen storage disease type Ib: a case report

Additional file 1. Neutrophil count (light grey triangles), 1,5AG (black circles) and 1,5AG6P (dark grey squares) before and after empagliflozin. Plasma 1,5-AG concentration dropped from ±250 μM before treatment to ±50 μM after 2 weeks on empagliflozin. Concentration of 1,5-AG stayed relatively constant until day + 164, before a change in the diet introducing a daily oral intake of carbohydrates. On day + 232, approximately 2 months after this change, plasma 1,5-AG was only very slightly increased to 60 μM. After treatment, 1,5-AG6P present in leukocytes and measured in whole blood samples was reduced by 4- to 5-fold when compared to values before starting empagliflozin. 1,5AG: 1,5-anhydroglucitol; 1,5AG6P: 1,5-anhydroglucitol-6-phosphate.