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Profiles of immune cell infiltration in head and neck squamous carcinoma
- Source :
- Bioscience Reports
- Publication Year :
- 2020
- Publisher :
- Portland Press Ltd., 2020.
-
Abstract
- Tumor immune infiltration cells (TIICs) are highly heterogeneous, not only in different cancer subtypes but also within different cancer regions. We conducted the Cell-type Identification using Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) method. We assessed the relative proportions of 22 TIICs in HNSC using publicly available TCGA transcriptional datasets, analyzed the proportions of TIICs between HNSC tissues and normal tissues, along with accompanying clinicopathological data, and the impact of TIICs on clinical outcome. After the filter criteria, a total of 395 patients were included in the analysis. We found significant differences in naïve B cells, monocytes, resting mast cells, activated mast cells, CD8+ T cells, and M0 macrophages between HNSC tissues and adjacent non-cancer tissues. We also found that some TIIC subgroups were significantly associated with clinical parameters. Moreover, the patients with low Tregs fraction had worse OS and DFS than those with high Tregs fraction. However, low M0 macrophages fraction was associated with better OS and DFS in HNSC patients. Moreover, Tregs and M0 macrophages are likely to be important determinants of prognosis, which may serve as a potential immunotherapy target for HNSC. Then, we screened the immune-related differentially expressed genes (DEGs), performed the GO and KEGG enrichment analysis, constructed the protein–protein interaction network, and screened the prognosis-related hub genes in HNSC. However, further clinical investigation and basic experiments are needed to validate our results, and uncover the molecular mechanisms interlinking TIICs in HNSC and their roles in prognosis and therapy.
- Subjects :
- Male
0301 basic medicine
medicine.medical_treatment
Biochemistry
0302 clinical medicine
Tumor-Associated Macrophages
Gene Regulatory Networks
Mast Cells
Protein Interaction Maps
Head and neck cancer
Diagnostics & Biomarkers
Research Articles
Cancer
Aged, 80 and over
Immune cell
Middle Aged
Gene Expression Regulation, Neoplastic
Phenotype
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Female
Signal Transduction
Adult
Bioinformatics
Naive B cell
Biophysics
Biology
Disease-Free Survival
Young Adult
03 medical and health sciences
Lymphocytes, Tumor-Infiltrating
Biomarkers, Tumor
medicine
Humans
KEGG
Molecular Biology
Aged
Squamous Cell Carcinoma of Head and Neck
RNA
Cell Biology
Immunotherapy
TCGA
medicine.disease
Lymphocyte Subsets
Squamous carcinoma
030104 developmental biology
Cancer research
Tumor Escape
prognosis
CD8
Subjects
Details
- ISSN :
- 15734935 and 01448463
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Bioscience Reports
- Accession number :
- edsair.doi.dedup.....0a85e5299ef3573e69c99fbaaa6c171f