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Phenytoin and folic acid: individualized drug-drug interaction
- Source :
- Therapeutic drug monitoring. 5(4)
- Publication Year :
- 1983
-
Abstract
- The effect of folic acid supplementation on the disposition of phenytoin and the resultant loss of seizure control in a male folate-deficient epileptic is reported. Due to the increase in tonic-clonic seizures after the initiation of folic acid (1 mg, orally) the sodium phenytoin dosage was increased by 130 mg until control was achieved. Because of these dosage changes, the Vmax and Km were calculated before and after initiation of the folic acid. The Vmax remained relatively the same, but the Km decreased after folate supplementation.
- Subjects :
- Pharmacology
Phenytoin
Male
Epilepsy
Chemistry
medicine.medical_treatment
Drug-drug interaction
Metabolism
Drug interaction
Middle Aged
medicine.disease
nervous system diseases
Anticonvulsant
Folic Acid
Pharmacokinetics
Folic acid
medicine
Humans
Pharmacology (medical)
Drug Interactions
medicine.drug
Subjects
Details
- ISSN :
- 01634356
- Volume :
- 5
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Therapeutic drug monitoring
- Accession number :
- edsair.doi.dedup.....0a858986032481ce12eb1e630bcb8ef9