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Trail Overexpression Inversely Correlates with Histological Differentiation in Intestinal-Type Sinonasal Adenocarcinoma

Authors :
Lorenzo Lo Muzio
Massimo Re
Corrado Rubini
Marco Mascitti
Andrea Santarelli
F. Bambini
Antonio Zizzi
Source :
International Journal of Surgical Oncology, Vol 2013 (2013), International Journal of Surgical Oncology
Publication Year :
2013
Publisher :
Hindawi Publishing Corporation, 2013.

Abstract

Introduction. Despite their histological resemblance to colorectal adenocarcinoma, there is some information about the molecular events involved in the pathogenesis of intestinal-type sinonasal adenocarcinomas (ITACs). To evaluate the possible role of TNF-related apoptosis-inducing ligand (TRAIL) gene defects in ITAC, by investigating the immunohistochemical expression of TRAIL gene product in a group of ethmoidal ITACs associated with occupational exposure.Material and Methods. Retrospective study on 23 patients with pathological diagnosis of primary ethmoidal ITAC. Representative formalin-fixed, paraffin-embedded block from each case was selected for immunohistochemical studies using the antibody against TRAIL. Clinicopathological data were also correlated with the staining results.Results. The immunohistochemical examination demonstrated that poorly differentiated cases showed a higher percentage of TRAIL expressing cells compared to well-differentiated cases. No correlation was found with other clinicopathological parameters, including T, stage and relapses.Conclusion. The relationship between upregulation of TRAIL and poorly differentiated ethmoidal adenocarcinomas suggests that the mutation of this gene, in combination with additional genetic events, could play a role in the pathogenesis of ITAC.

Details

Language :
English
ISSN :
20901402
Database :
OpenAIRE
Journal :
International Journal of Surgical Oncology
Accession number :
edsair.doi.dedup.....0a8407c6688dc62e45e9a4586933f9a0
Full Text :
https://doi.org/10.1155/2013/203873