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Trail Overexpression Inversely Correlates with Histological Differentiation in Intestinal-Type Sinonasal Adenocarcinoma
- Source :
- International Journal of Surgical Oncology, Vol 2013 (2013), International Journal of Surgical Oncology
- Publication Year :
- 2013
- Publisher :
- Hindawi Publishing Corporation, 2013.
-
Abstract
- Introduction. Despite their histological resemblance to colorectal adenocarcinoma, there is some information about the molecular events involved in the pathogenesis of intestinal-type sinonasal adenocarcinomas (ITACs). To evaluate the possible role of TNF-related apoptosis-inducing ligand (TRAIL) gene defects in ITAC, by investigating the immunohistochemical expression of TRAIL gene product in a group of ethmoidal ITACs associated with occupational exposure.Material and Methods. Retrospective study on 23 patients with pathological diagnosis of primary ethmoidal ITAC. Representative formalin-fixed, paraffin-embedded block from each case was selected for immunohistochemical studies using the antibody against TRAIL. Clinicopathological data were also correlated with the staining results.Results. The immunohistochemical examination demonstrated that poorly differentiated cases showed a higher percentage of TRAIL expressing cells compared to well-differentiated cases. No correlation was found with other clinicopathological parameters, including T, stage and relapses.Conclusion. The relationship between upregulation of TRAIL and poorly differentiated ethmoidal adenocarcinomas suggests that the mutation of this gene, in combination with additional genetic events, could play a role in the pathogenesis of ITAC.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Article Subject
Adenocarcinoma
lcsh:RC254-282
Pathogenesis
Gene product
TNF-Related Apoptosis-Inducing Ligand
Ethmoid Sinus
Ethmoid sinus
Occupational Exposure
medicine
Humans
Pathological
Aged
Retrospective Studies
biology
business.industry
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Occupational Diseases
Intestinal-Type Sinonasal Adenocarcinoma
medicine.anatomical_structure
Oncology
biology.protein
Immunohistochemistry
Surgery
Female
Antibody
business
Paranasal Sinus Neoplasms
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 20901402
- Database :
- OpenAIRE
- Journal :
- International Journal of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....0a8407c6688dc62e45e9a4586933f9a0
- Full Text :
- https://doi.org/10.1155/2013/203873