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Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives
- Source :
- Molecules, Molecules; Volume 13; Issue 10; Pages: 2557-2569, Molecules, Vol 13, Iss 10, Pp 2557-2569 (2008)
- Publication Year :
- 2008
- Publisher :
- MDPI, 2008.
-
Abstract
- A number of 3-substituted-2-(substituted-phenoxymethyl) quinazolin-4(3H)-one derivatives 4a,b, 5a-c, 6, 7a-f, 8a-e and 9a,b have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, 1H-NMR, MS). A preliminary evaluation of the anticonvulsant activity of the prepared compounds has indicated that compounds 4b, 7b-f, 8a and 9b exhibit significant anticonvulsant activity, while compounds 6, 8b and 8d show mild to moderate activity.
- Subjects :
- Stereochemistry
medicine.medical_treatment
piperazines
Pharmaceutical Science
Moderate activity
Article
Analytical Chemistry
lcsh:QD241-441
chemistry.chemical_compound
Structure-Activity Relationship
lcsh:Organic chemistry
Drug Discovery
medicine
Organic chemistry
Physical and Theoretical Chemistry
Chloroacetamide
Molecular Structure
Spectrum Analysis
Organic Chemistry
chloroacetamide
Quinazolin-4-(3H)-ones
Anticonvulsant
chemistry
Chemistry (miscellaneous)
Quinazolines
Molecular Medicine
anticonvulsant activity
Anticonvulsants
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 13
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....0a823e5047b50377496a066c2ece5d03