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Autophagy activated by SIRT6 regulates Aβ induced inflammatory response in RPEs
- Source :
- Biochemical and biophysical research communications. 496(4)
- Publication Year :
- 2018
-
Abstract
- Age-associated dysfunction of retinal pigment epithelial cells (RPEs) is considered to be the initial trigger of retinal diseases such as age-related macular degeneration. Although autophagy is upregulated in RPEs during the course of aging, little is known about how autophagy is regulated and its functional role in RPEs. In this study, we found that expression of Sirtuin 6 (SIRT6) and autophagic markers are upregulated in RPEs of aged mice where subretinal deposition of amyloid-β is accumulated and in amyloid-β stimulated RPEs. In addition, gain and loss-of-function studies confirmed the positive role of SIRT6 in regulating autophagy. Interesting, inhibition of autophagy attenuates amyloid-β stimulated inflammatory response in RPEs. Collectively, our findings uncover the autophagy modulated by SIRT6 may be a proinflammatory mechanism for amyloid-β induced RPE dysfunction.
- Subjects :
- 0301 basic medicine
SIRT6
Amyloid
Biophysics
Inflammation
Retinal Pigment Epithelium
Biochemistry
Proinflammatory cytokine
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
Downregulation and upregulation
medicine
Autophagy
Animals
Sirtuins
Molecular Biology
Cells, Cultured
Amyloid beta-Peptides
biology
Chemistry
Retinitis
Retinal
Epithelial Cells
Cell Biology
Cell biology
Mice, Inbred C57BL
030104 developmental biology
Gene Expression Regulation
Sirtuin
030221 ophthalmology & optometry
biology.protein
medicine.symptom
Inflammation Mediators
Subjects
Details
- ISSN :
- 10902104
- Volume :
- 496
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Biochemical and biophysical research communications
- Accession number :
- edsair.doi.dedup.....0a728b04730711b533df59e30091d884