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Drift of the HIV-1 Envelope Glycoprotein gp120 toward Increased Neutralization Resistance over the Course of the Epidemic: a Comprehensive Study Using the Most Potent and Broadly Neutralizing Monoclonal Antibodies
- Source :
- Journal of Virology. 88:13910-13917
- Publication Year :
- 2014
- Publisher :
- American Society for Microbiology, 2014.
-
Abstract
- Extending our previous analyses to the most recently described monoclonal broadly neutralizing antibodies (bNAbs), we confirmed a drift of HIV-1 clade B variants over 2 decades toward higher resistance to bNAbs targeting almost all the identified gp120-neutralizing epitopes. In contrast, the sensitivity to bNAbs targeting the gp41 membrane-proximal external region remained stable, suggesting a selective pressure on gp120 preferentially. Despite this evolution, selected combinations of bNAbs remain capable of neutralizing efficiently most of the circulating variants.
- Subjects :
- Male
medicine.drug_class
Immunology
HIV Infections
HIV Antibodies
HIV Envelope Protein gp120
Biology
Gp41
Monoclonal antibody
Hiv 1 envelope
Microbiology
Neutralization
Mice
Neutralization Tests
Virology
Vaccines and Antiviral Agents
medicine
Animals
Humans
Epidemics
chemistry.chemical_classification
Genetic Drift
Antibodies, Monoclonal
Antibodies, Neutralizing
HIV Envelope Protein gp41
Neutralizing epitope
chemistry
Insect Science
HIV-1
Glycoprotein
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....0a5ba34deaefedca3745d8851935b21c