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Urinary 3-methoxy, 4-hydroxyphenylethylene glycol and therapeutic response to maprotiline and indalpine in major depression
- Source :
- Journal of neural transmission. 66(1)
- Publication Year :
- 1986
-
Abstract
- The potential value of pretreatment urinary 3-methoxy, 4-hydroxyphenylethyleneglycol (MHPG) levels to predict the therapeutic response to antidepressants was studied by measuring urinary MHPG output in 42 depressed inpatients treated with a selective inhibitor of serotonin (Indalpine) or noradrenaline (Maprotiline) reuptake. Among the 42 depressed inpatients there were 33 cases of major depressive episode. Patients were treated for at least 3 weeks, firstly with intravenous infusions of maprotiline or indalpine which have been administered at random. No difference in pretreatment urinary MHPG levels was found between the responders to indalpine (1.08 +/- 0.48 micrograms/24 h/mg of creatinine) and the responders to maprotiline (1.15 +/- 0.62 micrograms/24 h/mg of creatinine). However, there was a difference in the pretreatment levels of urinary MHPG between the non-responders to indalpine (0.56 +/- 0.28 microgram/24 h/mg of creatinine) and the non-responders to maprotiline (1.37 +/- 0.68 micrograms/24 h/mg of creatinine). No correlation between this biochemical parameter and HDRS score was found. These results indicate that, in this study, there is no obvious relationship between the pretreatment urinary MHPG levels in depressed patients and their therapeutic response to specific inhibitors of noradrenaline or serotonin reuptake. However, there was a positive trend towards a lower pretreatment MHPG level to be associated with lack of response to indalpine.
- Subjects :
- Adult
Male
medicine.medical_specialty
Urinary system
Urine
Opium
Reuptake
Methoxyhydroxyphenylglycol
chemistry.chemical_compound
Glycols
Sex Factors
Piperidines
Internal medicine
medicine
Humans
Major depressive episode
Maprotiline
Biological Psychiatry
Anthracenes
Creatinine
business.industry
Depression
Age Factors
Middle Aged
Psychiatry and Mental health
Endocrinology
Neurology
chemistry
Indalpine
Female
Neurology (clinical)
Serotonin
medicine.symptom
business
medicine.drug
Subjects
Details
- Volume :
- 66
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of neural transmission
- Accession number :
- edsair.doi.dedup.....0a590adc3c9ffb869e926c59ae2cf147