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IL-37 Gene and Cholesterol Metabolism: Association of Polymorphisms with the Presence of Hypercholesterolemia and Cardiovascular Risk Factors. The GEA Mexican Study
- Source :
- Biomolecules, Vol 10, Iss 1409, p 1409 (2020), Biomolecules, Volume 10, Issue 10
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Interleukin 37 (IL-37) is an anti-inflammatory cytokine involved in the regulation of cholesterol homeostasis, reducing the levels of plasma cholesterol, fatty acids, and triglycerides. The aim of the present study was to evaluate the association of the IL-37 polymorphisms with the presence of hypercholesterolemia (HC), and with cardiovascular risk factors. Nine IL-37 polymorphisms (rs2708965, rs2708962, rs6717710, rs2708961, rs2708960, rs2708958, rs2723187, rs2708947, and rs2723192) were determined by TaqMan assays in a group of 1292 individuals (514 with and 778 without hypercholesterolemia) belonging to the cohort of the GEA Mexican Study. The associations were evaluated by logistic regression, using inheritance models adjusted by confounding variables. Under codominant 1 model, the rs2708961 (OR = 0.51, p = 0.02), rs2723187 (OR = 0.35, p = 0.005), and rs2708947 (OR = 0.49, p = 0.02) polymorphisms were associated with low risk of HC. The association of the polymorphisms with cardiovascular risk factors was evaluated independently in HC and non-HC individuals. In non-HC individuals, some polymorphisms were associated with the risk of having high levels of LDL-C, glucose, and high risk of T2DM, and low risk of having high visceral abdominal fat. On the other hand, in individuals with HC five, polymorphisms were associated with high levels of C-reactive protein. The IL-37 rs2708961, rs2723187, rs2708947 polymorphisms were associated with low risk of HC, and some IL-37 polymorphisms were associated with cardiometabolic factors in both individuals with and without HC.
- Subjects :
- 0301 basic medicine
Adult
Male
cardiovascular risk factors
medicine.medical_specialty
medicine.medical_treatment
Cardiovascular risk factors
lcsh:QR1-502
Inflammation
Logistic regression
Biochemistry
Article
lcsh:Microbiology
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Medicine
Humans
Molecular Biology
Gene
Mexico
Polymorphism, Genetic
Models, Genetic
hypercholesterolemia
business.industry
Confounding
Interleukin
Middle Aged
030104 developmental biology
Endocrinology
Cytokine
Cardiovascular Diseases
inflammation
Cohort
Female
medicine.symptom
business
polymorphisms
interleukin 37
030215 immunology
Interleukin-1
Subjects
Details
- Language :
- English
- Volume :
- 10
- Issue :
- 1409
- Database :
- OpenAIRE
- Journal :
- Biomolecules
- Accession number :
- edsair.doi.dedup.....0a536232bb56f425bc9eb87c70351a72