Back to Search
Start Over
Three distinct physical behavior types in fatigued patients with multiple sclerosis
- Source :
- Journal of NeuroEngineering and Rehabilitation, Journal of NeuroEngineering and Rehabilitation, Vol 16, Iss 1, Pp 1-9 (2019), Journal of NeuroEngineering and Rehabilitation, 16(1):105. BioMed Central, Journal of NeuroEngineering and Rehabilitation, 16(Article 105 (2019)), 1-9. London: Biomed Central, Braakhuis, H E M, Berger, M A M, van der Stok, G A, van Meeteren, J, de Groot, V, Beckerman, H, Bussmann, J B J, de Groot, V, Beckerman, H, Malekzadeh, A, van den Akker, L E, Looijmans, M, Sanches, S A, Dekker, J, Collette, E H, van Oosten, B W, Teunissen, C E, Blankenstein, M A, Eijssen, I C J M, Rietberg, M, Heine, M, Verschuren, O, Kwakkel, G, Visser-Meily, J M A, van de Port, I G L, Lindeman, E, Blikman, L J M, van Meeteren, J, Bussmann, J B J, Stam, H J, Hintzen, R Q, Hacking, H G A, Hoogervorst, E L, Frequin, S T F M, Knoop, H, de Jong, B A, Bleijenberg, G, de Laat, F A J, Verhulsdonck, M C, van Munster, E T L, Oosterwijk, C J & Aarts, G J 2019, ' Three distinct physical behavior types in fatigued patients with multiple sclerosis ', Journal of NeuroEngineering and Rehabilitation, vol. 16, no. 1, 105 . https://doi.org/10.1186/s12984-019-0573-1, https://doi.org/10.1186/s12984-019-0573-1, Journal of NeuroEngineering and Rehabilitation, 16(1). BioMed Central Ltd.
- Publication Year :
- 2019
-
Abstract
- Background Multiple sclerosis often leads to fatigue and changes in physical behavior (PB). Changes in PB are often assumed as a consequence of fatigue, but effects of interventions that aim to reduce fatigue by improving PB are not sufficient. Since the heterogeneous nature of MS related symptoms, levels of PB of fatigued patients at the start of interventions might vary substantially. Better understanding of the variability by identification of PB subtypes in fatigued patients may help to develop more effective personalized rehabilitation programs in the future. This study aimed to identify PB subtypes in fatigued patients with multiple sclerosis based on multidimensional PB outcome measures. Methods Baseline accelerometer (Actigraph) data, demographics and clinical characteristics of the TREFAMS-ACE participants (n = 212) were used for secondary analysis. All patients were ambulatory and diagnosed with severe fatigue based on a score of ≥35 on the fatigue subscale of the Checklist Individual Strength (CIS20r). Fifteen PB measures were used derived from 7 day measurements with an accelerometer. Principal component analysis was performed to define key outcome measures for PB and two-step cluster analysis was used to identify PB types. Results Analysis revealed five key outcome measures: percentage sedentary behavior, total time in prolonged moderate-to-vigorous physical activity, number of sedentary bouts, and two types of change scores between day parts (morning, afternoon and evening). Based on these outcomes three valid PB clusters were derived. Conclusions Patients with severe MS-related fatigue show three distinct and homogeneous PB subtypes. These PB subtypes, based on a unique set of PB outcome measures, may offer an opportunity to design more individually-tailored interventions in rehabilitation. Trial registration Clinical trial registration no ISRCTN 82353628, ISRCTN 69520623 and ISRCTN 58583714. Electronic supplementary material The online version of this article (10.1186/s12984-019-0573-1) contains supplementary material, which is available to authorized users.
- Subjects :
- Adult
Male
030506 rehabilitation
medicine.medical_specialty
Neurology
Evening
Multiple Sclerosis
Adolescent
medicine.medical_treatment
Psychological intervention
Health Informatics
multiple sclerose
hoofdcomponentenanalyse
lcsh:RC321-571
03 medical and health sciences
clusteranalyse
Young Adult
Cluster analysis
Accelerometry
medicine
Humans
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Fatigue
Aged
Behavior
Principal Component Analysis
Rehabilitation
business.industry
Multiple sclerosis
Research
Middle Aged
medicine.disease
Checklist
Clinical trial
Cross-Sectional Studies
Ambulatory
Physical therapy
lichamelijk gedrag
Female
0305 other medical science
business
Physical behavior
Subjects
Details
- Language :
- English
- ISSN :
- 17430003
- Volume :
- 16
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of NeuroEngineering and Rehabilitation
- Accession number :
- edsair.doi.dedup.....0a440c76f404a7b22178f7bf1464ed42