Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA1/GPR40), a Potential Target for the Treatment of Type II Diabetes

Authors :: Andreas Spinrath
Christian Urban
Andrew D. Bond
Elisabeth Christiansen
Evi Kostenis
Matthias U. Kassack
Nicole Merten
Alexandra Hamacher
Trond Ulven
Christel Drewke
Susanne Ullrich
Kasper K. Karlsen
Kathrin Liebscher
Source :: Christiansen, E, Urban, C, Merten, N, Liebscher, K, Karlsen, K, Hamacher, A, Spinrath, A, Bond, A, Drewke, C, Ullrich, S, Kassack, M, Kostenis, E & Ulven, T 2008, ' Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA1/GPR40), a Potential Target for the Treatment of Type II Diabetes ', Journal of Medicinal Chemistry, vol. 51, no. 22, pp. 7061-7064 . https://doi.org/10.1021/jm8010178
Publication Year :: 2008
Publisher :: American Chemical Society (ACS), 2008.
Abstract: Udgivelsesdato: 2008-Oct-24 A series of 4-phenethynyldihydrocinnamic acid agonists of the free fatty acid receptor 1 (FFA 1) has been discovered and explored. The preferred compound 20 (TUG-424, EC 50 = 32 nM) significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA 1 in metabolic diseases such as diabetes or obesity.

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