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Adrenocortical cancer: mortality, hormone secretion, proliferation and urine steroids – experience from a single centre spanning three decades
- Source :
- BMC Endocrine Disorders
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Background Adrenocortical carcinoma (ACC) is a rare malignant disease with a poor prognosis. Our aims were to study survival and to explore prognostic markers. Methods We retrospectively investigated the medical records of all 50 ACC patients at a single centre diagnosed between 1985 and 2012 and followed them up until 31/12/2014. Results Of this cohort, twenty six (52 %) were females. Adrenalectomy was performed in 48 patients (96 %), and twenty seven (54 %) were treated with adjuvant cytotoxic agents. The tumor sizes ranged from 6 to 20 cm. Overall survival time was 5.5 years (0.3–19.8), the two and five-year survival was 64 and 40 %, respectively. In ENSAT stage II 25/48 patients had a median survival of 7.0 years (0.7–15.5), in stage III 8/48 this was 1.9 (0.4 – 19.8), and in stage IV 15/48 it was 1.2 (0.3–3.6) years. Seventeen patients (34 %) were still alive at the end of 2014. The total follow-up time was 8.4 (0.3–19.8) years. Cell proliferation measured with Ki-67 had a median value of 15 % (2–80) and the urinary steroid profile was clearly pathologic in 29 of 43 (67 %) tested patients. The proliferation index did not significantly predict mortality (Ki-67 ≤ 10 vs. >10 %, 9.0 vs. 3.2 years, P = 0.0833), but resection margins did (R1 vs. R2, P = 0.0066; R0 vs. R2, P
- Subjects :
- Male
Adrenocortical carcinoma
Pathology
Survival
Proliferation index
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Gastroenterology
0302 clinical medicine
Adrenal Cortex Hormones
Stage (cooking)
Child
Aldosterone
Aged, 80 and over
biology
Adrenalectomy
General Medicine
Middle Aged
Prognosis
Child, Preschool
030220 oncology & carcinogenesis
Ki-67
Female
Research Article
Adult
medicine.medical_specialty
Adolescent
Urinary system
030209 endocrinology & metabolism
Urinary steroid profile
Young Adult
03 medical and health sciences
Internal medicine
medicine
Humans
Mortality
Survival analysis
Aged
Cell Proliferation
Retrospective Studies
business.industry
Retrospective cohort study
medicine.disease
Survival Analysis
Adrenal Cortex Neoplasms
Hormones
biology.protein
business
Subjects
Details
- ISSN :
- 14726823
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- BMC Endocrine Disorders
- Accession number :
- edsair.doi.dedup.....0a2bde1131cdb2dc5e31f6893f0eacf3