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14-3-3ζ promotes esophageal squamous cell carcinoma invasion by repressing S1PR2 protein expression through NF-κB signaling
- Source :
- Archives of Biochemistry and Biophysics. 643:7-13
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- 14-3-3ζ is overexpressed in several cancers, including esophageal squamous cell carcinoma (ESCC), and plays an important role in tumorigenesis. However, the mechanisms underlying its tumorigenesis remain unclear. Here we report that 14-3-3ζ was upregulated in ESCC tumors, compared with adjacent normal tissues; 14-3-3ζ levels were positively correlated with ESCC lymph node metastasis and recurrence. Overexpression of 14-3-3ζ promoted the tumor growth and invasion of ESCC in vitro and in vivo, whereas depletion of 14-3-3ζ suppressed these effects. Moreover, 14-3-3ζ reduces expression of genes mediating S1P/S1PR2 signaling, and this effect is mediated through activation of NF- κ B. Taken together, 14-3-3ζ contributes to ESCC tumorigenesis and progression through repressing S1PR2 signaling and may act as a new therapeutic target for ESCC.
- Subjects :
- Male
0301 basic medicine
Biophysics
Down-Regulation
Biology
medicine.disease_cause
Biochemistry
Esophageal squamous cell carcinoma
Protein expression
03 medical and health sciences
Downregulation and upregulation
In vivo
Cell Line, Tumor
medicine
Humans
Neoplasm Invasiveness
Sphingosine-1-Phosphate Receptors
neoplasms
Molecular Biology
Gene
Cell Proliferation
S1PR2
NF-kappa B
Middle Aged
Prognosis
digestive system diseases
In vitro
Receptors, Lysosphingolipid
030104 developmental biology
14-3-3 Proteins
Cancer research
Female
Esophageal Squamous Cell Carcinoma
Carcinogenesis
Signal Transduction
Subjects
Details
- ISSN :
- 00039861
- Volume :
- 643
- Database :
- OpenAIRE
- Journal :
- Archives of Biochemistry and Biophysics
- Accession number :
- edsair.doi.dedup.....0a1bc64c45948b302a13ea8178a98373