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Synthesis of cyano-2,3-dihydropyrrolo[1,2-f]phenanthridine derivatives via a domino-Knoevenagel-cyclization
- Source :
- Molecular Diversity. 15:197-201
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- In a new multicomponent reaction phenanthridine reacts with isocyanides and malonitrile in the presence of benzaldehyde derivatives to produce 2-aryl-3-(alkyl- or arylimino)-2,3-dihydropyrrolo[1,2-f]phenanthridine-1,1(12b H)-dicarbonitrile in a simple, mild, and efficient protocol in excellent yields.
- Subjects :
- chemistry.chemical_classification
Phenanthridine
Pyridines
Organic Chemistry
Temperature
General Medicine
Medicinal chemistry
Catalysis
Domino
Phenanthridines
Inorganic Chemistry
Benzaldehyde
chemistry.chemical_compound
chemistry
Cyclization
Benzaldehydes
Nitriles
Drug Discovery
Organic chemistry
Knoevenagel condensation
Physical and Theoretical Chemistry
Molecular Biology
Alkyl
Information Systems
Subjects
Details
- ISSN :
- 1573501X and 13811991
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Molecular Diversity
- Accession number :
- edsair.doi.dedup.....0a1a4272076e0dc60d7e3766661e15d1
- Full Text :
- https://doi.org/10.1007/s11030-010-9254-5