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CT cholangiography in potential liver donors: effect of premedication with intravenous morphine on biliary caliber and visualization
- Source :
- Radiology. 247(3)
- Publication Year :
- 2008
-
Abstract
- To retrospectively determine whether premedication with intravenously administered morphine improves bile duct caliber and visualization in potential liver donors undergoing computed tomographic (CT) cholangiography.This was a retrospective single institution study approved by the institutional review board and compliant with requirements of the HIPAA. Multidetector CT cholangiography was performed after slow infusion of 20 mL of iodipamide meglumine 52% diluted in 80 mL of normal saline in 143 consecutive potential liver donors (81 men and 62 women; mean age, 37 years); 43 received premedication with intravenous morphine sulfate (0.04 mg per kilogram of body weight) and 100 did not. Two independent readers recorded common bile duct diameter and area on axial CT images. Readers also scored bile duct visualization, including all second-order biliary branches, on a four-point scale (0, not seen; 3, excellent visualization).For scans obtained without and those obtained with morphine, there was no significant difference in the mean common bile duct diameter (4.1 vs 4.3 mm for reader 1 and 4.4 vs 4.6 mm for reader 2, respectively; P.39 for both readers), in common bile duct area (20.7 vs 21.5 mm(2), for reader 1 and 21.3 vs 20.2 mm(2) for reader 2, respectively, P.60 for both), or in second-order bile duct visualization score (2.34 vs 2.36 for reader 1 and 2.58 vs 2.50 for reader 2, respectively; P.5 for both).The results suggest that premedication with intravenous morphine prior to CT cholangiography in potential liver donors does not increase bile duct caliber or improve biliary visualization.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Premedication
Iodipamide
Contrast Media
Iodipamide Meglumine
Cholangiography
Living Donors
Medicine
Humans
Radiology, Nuclear Medicine and imaging
Biliary Tract
Saline
Retrospective Studies
Common bile duct
medicine.diagnostic_test
Morphine
business.industry
Bile duct
Middle Aged
Liver Transplantation
medicine.anatomical_structure
Biliary tract
Radiographic Image Interpretation, Computer-Assisted
Female
Radiology
business
Tomography, X-Ray Computed
medicine.drug
Subjects
Details
- ISSN :
- 15271315
- Volume :
- 247
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Radiology
- Accession number :
- edsair.doi.dedup.....0a139db9550c35895aeb2971b918e656