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The combination of strong expression of ZNF143 and high MIB-1 labelling index independently predicts shorter disease-specific survival in lung adenocarcinoma
- Source :
- British Journal of Cancer
- Publication Year :
- 2014
- Publisher :
- Nature Publishing Group, 2014.
-
Abstract
- Background: The transcription factor, zinc finger protein 143 (ZNF143), positively regulates many cell-cycle-related genes. The ZNF143 would show high expression of multiple solid tumours related closely to cancer cell growth, similar to the widely accepted Ki67 (MIB-1) protein, but the underlying mechanisms for ZNF143 remain unclear. We investigated the association of ZNF143 expression with clinicopathological features and prognoses of patients with lung adenocarcinoma. Methods: Expressions of ZNF143 and MIB-1 were immunohistochemically analysed in 183 paraffin-embedded tumour samples of patients with lung adenocarcinoma. The ZNF143 expression was considered to be strong when >30% of the cancer cells demonstrated positive staining. Results: Strong ZNF143+ expression showed a significantly close relationship to pathologically moderate to poor differentiation and highly invasive characteristics. The ZNF143 positivity potentially induced cell growth of lung adenocarcinoma, correlated significantly with high MIB-1 labelling index (⩾10%). Univariate and multivariate analyses demonstrated that both strong ZNF143+ and the high MIB-1 index group have only and significantly worse survival rates. Conclusions: The combination of strong ZNF143 expression and high MIB-1 index potentially predicts high proliferating activity and poor prognosis in patients with lung adenocarcinoma, and may offer a therapeutic target against ZNF143.
- Subjects :
- Adult
Male
Cancer Research
Pathology
medicine.medical_specialty
Mitotic index
Lung Neoplasms
Molecular Sequence Data
Biology
Adenocarcinoma
Immunoenzyme Techniques
Labelling
medicine
Mitotic Index
cell growth
Humans
Neoplasm Invasiveness
Amino Acid Sequence
neoplasms
Molecular Diagnostics
Survival analysis
Aged
Retrospective Studies
Aged, 80 and over
Lung
Disease specific survival
Cell Differentiation
Middle Aged
medicine.disease
lung adenocarcinoma
MIB-1
Prognosis
Survival Analysis
digestive system diseases
Peptide Fragments
Neoplasm Proteins
ZNF143
medicine.anatomical_structure
Ki-67 Antigen
Treatment Outcome
Oncology
Immunoenzyme techniques
Cancer research
Trans-Activators
Female
Neoplasm Grading
Cell Division
Subjects
Details
- Language :
- English
- ISSN :
- 15321827 and 00070920
- Volume :
- 110
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....09fe55e2b35fe655d4c4b47205536ad8