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Protection by hot water extract of Panax notoginseng on chronic ethanol-induced hepatotoxicity
- Source :
- Phytotherapy research : PTR. 17(9)
- Publication Year :
- 2003
-
Abstract
- The purpose of this study was to investigate the antioxidant effects of a hot water extract of Panax notoginseng (PNG) against chronic ethanol-induced hepatotoxicity. Fifty mice were divided into five equal groups with 10 in each group. Group 1 (control) received saline, whereas group 2 received ethanol (70%, 0.1 mL, p.o.) once daily for 4 weeks, which induced hepatotoxicity, manifested biochemically by a significant elevation of serum enzyme activities, such as SGOT and SGPT. Hepatotoxicity was further evidenced by a significant increase in the hepatic lipid peroxidation measured. Groups 3–5 were administered a hot water extract of PNG at doses of 10, 25 and 50 mg/kg 2 weeks after initiating oral administration of ethanol, for a further 2 weeks. PNG ameliorated the rise in serum sGOT and sGPT induced by chronic ethanol administration. The mice were killed after PNG administration. In a separate study, PNG inhibited the lipid peroxidation in the mouse liver homogenate induced by ethanol in a dose-dependent manner. The findings indicate that PNG is an efficient cytoprotective agent against chronic ethanol-induced hepatotoxicity, possibly through inhibition of the production of oxygen-free radicals that cause lipid peroxidation. Copyright © 2003 John Wiley & Sons, Ltd.
- Subjects :
- Male
Antioxidant
medicine.medical_treatment
Administration, Oral
Panax
Pharmacology
Pharmacognosy
Antioxidants
law.invention
Lipid peroxidation
chemistry.chemical_compound
Inhibitory Concentration 50
Mice
Liver Function Tests
Oral administration
law
parasitic diseases
Medicine
Animals
Panax notoginseng
Mice, Inbred ICR
biology
Dose-Response Relationship, Drug
Ethanol
business.industry
Plant Extracts
biology.organism_classification
Malondialdehyde
chemistry
Biochemistry
Liver
Toxicity
Chemical and Drug Induced Liver Injury
business
Phytotherapy
Subjects
Details
- ISSN :
- 0951418X
- Volume :
- 17
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Phytotherapy research : PTR
- Accession number :
- edsair.doi.dedup.....09faf2cc6afc51c3bf7226745c509a46