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The expression and significance of leukemia inhibitory factor, interleukin-6 and vascular endothelial growth factor in Chinese patients with endometriosis
- Source :
- Archives of Gynecology and Obstetrics.
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- To observe the levels of leukemia inhibitory factor (LIF), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in blood, peritoneal fluid, ectopic endometrial tissue, and ectopic endometrial stromal cells of patients with endometriosis, and to compare expression of IL-6, LIF and VEGF expression between endometriotic and non-endometriotic patients underwent laparoscopic surgery. Thirty-one patients who underwent laparoscopic surgery for endometriosis in our hospital from January 2018 to January 2020 were included in the observation group, and 32 patients who underwent laparoscopic surgery for uterine fibroids, ovarian serous cystadenoma, and ovarian teratomas, were included in the control group. The levels of LIF, IL-6 and VEGF in the blood and peritoneal fluid of the two groups of patients were detected. The levels of LIF, IL-6 and VEGF in ectopic endometrial tissue and self-paired eutopic endometrial tissue, ectopic endometrial stromal cells and self-paired eutopic endometrial stromal cells of patients in the observation group were detected. After treating the primary cultured ectopic endometrial stromal cells with LIF and IL-6 alone or in combination, the changes of VEGF mRNA of ectopic endometrial stromal cells and the VEGF levels in the supernatant were observed. The levels of LIF, IL-6 and VEGF in the blood and peritoneal fluid of the observation group were all higher than those of the control group (P
- Subjects :
- Adult
Vascular Endothelial Growth Factor A
China
Stromal cell
Uterine fibroids
Endometriosis
Leukemia Inhibitory Factor
Andrology
Endometrium
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Asian People
Humans
Medicine
Interleukin 6
030219 obstetrics & reproductive medicine
Ovarian serous cystadenoma
biology
Interleukin-6
Vascular Endothelial Growth Factors
business.industry
Peritoneal fluid
Obstetrics and Gynecology
General Medicine
medicine.disease
Vascular endothelial growth factor
chemistry
030220 oncology & carcinogenesis
biology.protein
Female
Laparoscopy
Stromal Cells
business
Leukemia inhibitory factor
Subjects
Details
- ISSN :
- 14320711 and 09320067
- Database :
- OpenAIRE
- Journal :
- Archives of Gynecology and Obstetrics
- Accession number :
- edsair.doi.dedup.....09f0d937b09d6ff0125d70126d5582bf