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Synergistic Effect ofHelicobacter pyloriVirulence Factors and Interleukinâ1 Polymorphisms for the Development of Severe Histological Changes in the Gastric Mucosa
- Source :
- The Journal of Infectious Diseases. 188:272-281
- Publication Year :
- 2003
- Publisher :
- Oxford University Press (OUP), 2003.
-
Abstract
- Polymorphisms of the IL-1B and IL-1RN genes (which encode interleukin [IL]-1beta and IL-1 receptor antagonist, respectively) have been associated with hypochlorhydria and gastric cancer. We investigated the influence of bacterial virulence factors and host IL-1 polymorphisms on the development of histologic abnormalities in 210 Helicobacter pylori-infected patients with chronic gastritis. cagA(+)/vacAs1(+) H. pylori strains were associated with intestinal metaplasia (IM), atrophic gastritis (AG), and severe inflammation. Carriers of the proinflammatory IL-1B -511T/-31C and IL-1RN*2 alleles had an increased risk for the development of AG, IM, and severe inflammation, with odds ratios (ORs) of 1.7 (95% confidence interval [CI], 0.8-3.4) to 4.4 (95% CI, 1.5-12.9). The highest prevalence of severe gastric abnormalities was found in patients with both host and bacterial high-risk genotypes (cagA(+)/vacAs1(+)/IL-1B -511T/IL-1RN*2), with ORs of 24.8 (95% CI, 5.2-117.3) for severe lymphocytic infiltration, 9.5 (95% CI, 2.8-32.1) for severe granulocytic infiltration, 6.0 (95% CI, 2.4-15.5) for IM, and 2.4 (95% CI, 0.93-6.2) for AG. Combined bacterial/host genotyping thus may provide a clinical tool to identify patients at high risk of developing cancer.
- Subjects :
- Adult
Atrophic gastritis
Stomach Diseases
Chronic gastritis
Helicobacter Infections
Gastric mucosa
medicine
Humans
Immunology and Allergy
CagA
Genetic Predisposition to Disease
Helicobacter
Alleles
Polymorphism, Genetic
Helicobacter pylori
Virulence
biology
Stomach
Intestinal metaplasia
Interleukin
biology.organism_classification
medicine.disease
Infectious Diseases
medicine.anatomical_structure
Gastric Mucosa
Immunology
Interleukin-1
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 188
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....09e79c90590e1da5f86b85ac244bedd3