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B1 and B2 antagonists and bradykinin-induced blood flow in rat skin inflammation
- Source :
- Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 51(6)
- Publication Year :
- 2002
-
Abstract
- Objective and design: The aim of the present study was to examine the contribution of the two kinin receptors B1 and B2 to the increased blood flow observed in response to bradykinin (BK) in a blister model under different injury conditions.¶Material: Young male Sprague-Dawley rats weighing 250-350 g were used.¶Methods: A vacuum-induced blister was raised in the rat hind paw and blood flow measured in the superfused blister base under four different conditions including, early phase acute injury; late phase acute injury; recurrent injury and early phase acute injury in the setting of chronic nerve damage. BK (10 μM) was superfused alone, or in the presence of the B1 antagonist DesArg9Leu8BK (DALBK), (10 nM) and/or the B2 antagonist [D-Arg,Hyp3,Thi5 D-Tic7,Oic8] Bradykinin (HOE 140) (10 nM).¶Results: HOE 140 significantly inhibited the BK response in all models. Significant inhibition of BK-induced vasodilatation by DALBK was only observed in the late phase acute and recurrent injury models.¶Conclusions: The results suggest that the involvement of the inducible B1 receptor in skin inflammation site is related to the site, duration and recurrence of the injury condition.
- Subjects :
- Male
Nitroprusside
Allergy
Receptor, Bradykinin B2
Immunology
Bradykinin
Inflammation
Vasodilation
Dermatitis
Pharmacology
Receptor, Bradykinin B1
Rats, Sprague-Dawley
chemistry.chemical_compound
medicine
Animals
Receptor
Bradykinin Receptor Antagonists
Skin
business.industry
Microcirculation
Receptors, Bradykinin
Antagonist
Blood flow
Kinin
medicine.disease
Rats
chemistry
Regional Blood Flow
Anesthesia
medicine.symptom
business
Subjects
Details
- ISSN :
- 10233830
- Volume :
- 51
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Inflammation research : official journal of the European Histamine Research Society ... [et al.]
- Accession number :
- edsair.doi.dedup.....09dfcad380da8f65a4f43c99a49d9342