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Association between serum Toll-like receptor 4 and 8-hydroxy-2′-deoxyguanosine levels with disease activity in rheumatoid arthritis patients
- Source :
- Egyptian Rheumatologist, Vol 42, Iss 2, Pp 95-99 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Aim of the work: Considering the importance of toll-like receptor (TLR) 4 and oxidative stress in the pathogenesis of autoimmune disorders, present study was designed to assess serum TLR4, 8-hydroxy-2′-deoxyguanosine (8-OHdG) as a marker of oxidative DNA damage, and total antioxidant capacity (TAC) in rheumatoid arthritis (RA) patients and to study their relation with disease activity and their predictive potential. Patients and methods: 44 RA patients and 44 matched controls were studied. Disease activity score (DAS-28) was assessed. Serum TLR4, 8-OHdG and TAC were measured. Results: The mean age of patients was 44 ± 10.4 years, 33 females and 11 males with and disease duration 5.5 ± 3.8 months. The mean DAS-28 was 4.6 ± 0.6 (3.45–6.01). Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) were both positive in 20 patients. Compared to control, the mean ± SD of serum TLR4 (2.41 ± 4.50 vs. 1.20 ± 1.67 ng/ml), and 8-OHdG (67.67 ± 20.57 vs. 45.34 ± 30.61 ng/ml) were significantly higher in patients (p
- Subjects :
- lcsh:Immunologic diseases. Allergy
030203 arthritis & rheumatology
medicine.medical_specialty
business.industry
8-Hydroxy-2'-deoxyguanosine
Disease
medicine.disease_cause
medicine.disease
Gastroenterology
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Rheumatology
Internal medicine
Rheumatoid arthritis
medicine
TLR4
Rheumatoid factor
030212 general & internal medicine
lcsh:RC581-607
Receptor
business
Oxidative stress
Subjects
Details
- ISSN :
- 11101164
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- The Egyptian Rheumatologist
- Accession number :
- edsair.doi.dedup.....09df964d34dd943f7e8672d69d382e67