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Localized Partitioning of Enantiomers in Solid Samples of Sulfoxides: Importance of Sampling Method in Determination of Enantiopurity
- Source :
- The Journal of Organic Chemistry. 85:10216-10221
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- Localized partitioning of amorphous enantioenriched aryl benzyl sulfoxides in the solid state can lead to substantial variation in enantiopurities, even for sulfoxides which do not show detectable levels of self-disproportionation of enantiomers (SDE) during chromatography on an achiral stationary phase. The importance of preparation of representative samples of enantioenriched sulfoxides for chiral HPLC to enable reproducible results is clear.
- Subjects :
- Importance sampling
Chiral sulfoxides
Solid-state
Efficient asymmetric oxidation
Sulfides
Ligands
Representative sample
010402 general chemistry
01 natural sciences
Sde
chemistry.chemical_compound
Chiral HPLC
Disproportionations
Self-disproportionation
Organic chemistry
Chromatography
010405 organic chemistry
Aryl
fungi
Organic Chemistry
Solid samples
food and beverages
Enantiopurity
3. Good health
0104 chemical sciences
Amorphous solid
Chiral column chromatography
Enantiomers
chemistry
Stationary phase
Sampling method
Enantiomer
Substantial variations
Subjects
Details
- ISSN :
- 15206904 and 00223263
- Volume :
- 85
- Database :
- OpenAIRE
- Journal :
- The Journal of Organic Chemistry
- Accession number :
- edsair.doi.dedup.....09d3df561e2770a6f516379a5f557771