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Reduced signal propagation elicited by frontal transcranial magnetic stimulation is associated with oligodendrocyte abnormalities in treatment-resistant depression

Authors :
Masataka Wada
Shinichiro Nakajima
Shiori Honda
Mayuko Takano
Keita Taniguchi
Sakiko Tsugawa
Yu Mimura
Nanao Hattori
Shinsuke Koike
Reza Zomorrodi
Daniel M. Blumberger
Zafiris J. Daskalakis
Masaru Mimura
Yoshihiro Noda
Source :
Journal of Psychiatry and Neuroscience. 47:E325-E335
Publication Year :
2022
Publisher :
CMA Impact Inc., 2022.

Abstract

The efficacy of repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (dlPFC) has been established in patients with treatment-resistant depression (TRD), suggesting that alterations in signal propagation from the left dlPFC to other brain regions may be linked to the pathophysiology of TRD. Alterations at the cellular level, including dysfunction of oligodendrocytes, may contribute to these network abnormalities. The objectives of the present study were to compare signal propagation from the left dlPFC to other neural networks in patients with TRD and healthy controls. We used TMS combined with electroencephalography to explore links between cell-specific gene expression and signal propagation in TRD using a virtual-histology approach.We examined source-level estimated signal propagation from the left dlPFC to the 7 neural networks in 60 patients with TRD and 30 healthy controls. We also calculated correlations between the interregional profiles of altered signal propagation and gene expression for 9 neural cell types derived from the Allen Human Brain Atlas data set.Signal propagation from the left dlPFC to the salience network was reduced in the θ and α bands in patients with TRD (These results show only part of the pathophysiology of TRD, because stimulation was limited to the left dlPFC.Reduced signal propagation from the left dlPFC to the salience network may represent a pathophysiological endophenotype of TRD; this finding may be associated with reduced expression of oligodendrocytes.

Details

ISSN :
11804882
Volume :
47
Database :
OpenAIRE
Journal :
Journal of Psychiatry and Neuroscience
Accession number :
edsair.doi.dedup.....09cb91f4fad773efee0d633bd451d402
Full Text :
https://doi.org/10.1503/jpn.220102