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Hemodynamic durability of transcatheter aortic valves using the updated Valve Academic Research Consortium‐2 criteria
- Source :
- Catheterization and Cardiovascular Interventions. 93:729-738
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- OBJECTIVES We investigated the hemodynamic durability of the transcatheter aortic valves (TAVs) using the updated Valve Academic Research Consortium-2 (VARC-2) criteria. BACKGROUND The updated VARC-2 consensus criteria combine flow-dependent and flow-independent echocardiographic parameters for hemodynamic assessment of TAVR. Data on the hemodynamic durability of TAV and clinical risk factors associated with valve hemodynamic deterioration (VHD) are lacking. METHODS All patients (n = 276) who received TAV between 2006 and 2012 and had ≥2 follow-up echocardiograms were studied. RESULTS During a median follow up period of 3.3 (1.8-4.4) years, 8 patients (3%) developed moderate to severe valve stenosis per the VARC-2 criteria, while 20 had mild stenosis. In a Cox proportional hazards model analysis, moderate to severe stenosis by VARC-2 criteria was associated with younger age (P = 0.03, HR 0.94), absence of dual antiplatelet therapy (DAPT) (P = 0.026, HR 0.18), and lower baseline left ventricular ejection fraction (LVEF) (P = 0.006, HR 0.94). Longitudinal analysis using a mixed effect model showed that presence of stenosis by VARC-2 criteria was associated with an increase in aortic valve mean gradient (P
- Subjects :
- Male
Aortic valve
medicine.medical_specialty
Time Factors
Transcatheter aortic
Hemodynamics
030204 cardiovascular system & hematology
Prosthesis Design
Risk Assessment
Severity of Illness Index
Ventricular Function, Left
Transcatheter Aortic Valve Replacement
03 medical and health sciences
0302 clinical medicine
Recurrence
Risk Factors
Median follow-up
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
030212 general & internal medicine
Aged
Retrospective Studies
Aged, 80 and over
Bioprosthesis
Ejection fraction
Proportional hazards model
business.industry
Age Factors
Valve stenosis
Aortic Valve Stenosis
General Medicine
medicine.disease
Prosthesis Failure
Stenosis
Treatment Outcome
medicine.anatomical_structure
Aortic Valve
Heart Valve Prosthesis
Cardiology
Female
Stress, Mechanical
Cardiology and Cardiovascular Medicine
business
Platelet Aggregation Inhibitors
Subjects
Details
- ISSN :
- 1522726X and 15221946
- Volume :
- 93
- Database :
- OpenAIRE
- Journal :
- Catheterization and Cardiovascular Interventions
- Accession number :
- edsair.doi.dedup.....09c8172fa585bb06f1474eccfba6766f