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Psoriasis and polycystic ovary syndrome: a new link in different phenotypes
- Source :
- European Journal of Obstetrics & Gynecology and Reproductive Biology. 191:101-105
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Objective Women affected by PCOS and psoriasis are more likely to have insulin-resistance, hyperinsulinemia, reduced HDL cholesterol levels and a more severe degree of skin disease than those with psoriasis alone. The mechanism underlying this association between PCOS and psoriasis is currently unknown. The aim of the present study was to evaluate the features of psoriasis and the psoriasis severity scores in the different PCOS phenotypes and in age and body mass index (BMI)-matched psoriatic control patients. Study design A cross-sectional study was performed on 150 psoriatic patients: 94 PCOS and 56 age- and BMI-matched controls. PCOS patients were diagnosed and divided into four phenotypes according to Rotterdam criteria: A – patients with complete phenotype with hyperandrogenism (H) plus oligoamenorrhea (O) plus polycystic ovary (PCO) on ultrasound examination; B – patients with H plus O (without PCO); C – patients with H plus PCO (ovulatory phenotype); D – patients with O plus PCO (without H). The patient's Psoriasis Area and Severity Index (PASI) as well as the Physician's Global Assessment (PGA) were calculated. A PASI score ≥10 was correlated with common indicator of severe disease. A PGA ≥4 was considered as a condition of moderate to severe disease. Results Among the four phenotypes investigated, the group with complete phenotype (H plus O plus PCO) had a higher prevalence of patients with patient's PASI ≥10 compared to controls (Odds Ratio (OR) 4.71, 95% confidence intervals (CI) 1.59–13.95). The group with O plus PCO had a higher prevalence of patients with PGA ≥4 compared to controls (OR 26.79, 95% CI 3.40–211.02) while the ovulatory group had a lower prevalence of patients with PGA ≥4 (OR 0.06, 95% CI 0.01–0.51). Conclusions The ovulatory phenotype displays a milder psoriasis form than other phenotypes while the phenotypes with oligoamenorrhea presented higher severity scores of disease than other phenotypes and control group.
- Subjects :
- Adult
medicine.medical_specialty
Outpatient Clinics, Hospital
Rome
Severity of Illness Index
Gastroenterology
Body Mass Index
Cohort Studies
Young Adult
Hospitals, Urban
Psoriasis Area and Severity Index
Psoriasis
Internal medicine
Prevalence
PCOS
medicine
Hyperinsulinemia
Humans
Settore MED/42 - IGIENE GENERALE E APPLICATA
Retrospective Studies
business.industry
Hyperandrogenism
Age Factors
Obstetrics and Gynecology
Odds ratio
Overweight
medicine.disease
Oligoamenorrhea
Polycystic ovary
Confidence interval
Oligomenorrhea
Phenotypes
Cross-Sectional Studies
Settore MED/40 - GINECOLOGIA E OSTETRICIA
Endocrinology
Reproductive Medicine
Female
business
Body mass index
Anovulation
Polycystic Ovary Syndrome
Subjects
Details
- ISSN :
- 03012115
- Volume :
- 191
- Database :
- OpenAIRE
- Journal :
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Accession number :
- edsair.doi.dedup.....09c6f90f956dc0ddbc44c3f5b2aa19ce