Back to Search
Start Over
The First Stage of Cardinal Direction Selectivity Is Localized to the Dendrites of Retinal Ganglion Cells
- Source :
- Neuron, Yonehara, K, Farrow, K, Ghanem, A, Hillier, D, Balint, K, Teixeira, M, Jüttner, J, Noda, M, Neve, R L, Conzelmann, K-K & Roska, B 2013, ' The first stage of cardinal direction selectivity is localized to the dendrites of retinal ganglion cells ', Neuron, vol. 79, no. 6, pp. 1078-85 . https://doi.org/10.1016/j.neuron.2013.08.005
- Publisher :
- Elsevier Inc.
-
Abstract
- Inferring the direction of image motion is a fundamental component of visual computation and essential for visually guided behavior. In the retina, the direction of image motion is computed in four cardinal directions, but it is not known at which circuit location along the flow of visual information the cardinal direction selectivity first appears. We recorded the concerted activity of the neuronal circuit elements of single direction-selective (DS) retinal ganglion cells at subcellular resolution by combining GCaMP3-functionalized transsynaptic viral tracing and two-photon imaging. While the visually evoked activity of the dendritic segments of the DS cells were direction selective, direction-selective activity was absent in the axon terminals of bipolar cells. Furthermore, the glutamate input to DS cells, recorded using a genetically encoded glutamate sensor, also lacked direction selectivity. Therefore, the first stage in which extraction of a cardinal motion direction occurs is the dendrites of DS cells.
- Subjects :
- Retinal Ganglion Cells
Retinal Bipolar Cells
Follistatin-Related Proteins
Patch-Clamp Techniques
Nerve net
Neuroscience(all)
Green Fluorescent Proteins
Motion Perception
Action Potentials
Glutamic Acid
Mice, Transgenic
Optogenetics
Biology
Visual system
In Vitro Techniques
Retinal ganglion
Retina
Choline O-Acetyltransferase
03 medical and health sciences
Mice
0302 clinical medicine
Imaging, Three-Dimensional
Transduction, Genetic
Orientation
medicine
Animals
Visual Pathways
Motion perception
Axon
030304 developmental biology
0303 health sciences
Microscopy, Confocal
General Neuroscience
Anatomy
Dendrites
Electric Stimulation
Mice, Inbred C57BL
medicine.anatomical_structure
Animals, Newborn
Rabies virus
Synapses
Nerve Net
Neuroscience
030217 neurology & neurosurgery
Cardinal direction
Subjects
Details
- Language :
- English
- ISSN :
- 08966273
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Neuron
- Accession number :
- edsair.doi.dedup.....09b9c47ca062f3ca3b475ac2d410fce1
- Full Text :
- https://doi.org/10.1016/j.neuron.2013.08.005