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What factors determine the survival of patients with an acute exacerbation of interstitial lung disease after lung cancer resection?
- Source :
- Surgery today. 48(4)
- Publication Year :
- 2017
-
Abstract
- Acute exacerbation of interstitial pneumonia (AEIP) is a leading cause of death after lung cancer resection in patients with interstitial lung disease. We retrospectively analyzed 1763 patients with non-small cell lung cancer with a clinical diagnosis of interstitial lung disease (ILD) who underwent lung cancer resection between 2000 and 2009 at 61 hospitals in Japan. AEIP occurred in 164 of 1763 (9.3%) patients with a mortality rate of 43.9% (72/164). Univariate and multivariate analyses were carried out to identify possible risk factors of fatal AEIP. We then analyzed the 164 patients who developed postoperative AEIP and identified the preoperative and postoperative risk factors. A multivariate regression analysis identified that the sex, percent vital capacity, neoadjuvant radiation, preoperative history of AEIP, preoperative use of steroids, usual interstitial pneumonia pattern on CT, and surgical procedures were independent preoperative risk factors for death due to AEIP. ILD patients with emphysema somehow showed a lower risk of fatal AEIP than those without emphysema in this study. This study revealed eight risk factors for fatal AEIP.
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
Lung Neoplasms
Exacerbation
Vital Capacity
030204 cardiovascular system & hematology
Lower risk
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Sex Factors
Usual interstitial pneumonia
Risk Factors
Internal medicine
Carcinoma, Non-Small-Cell Lung
Cause of Death
medicine
Humans
Lung cancer
Diffuse alveolar damage
Pneumonectomy
Idiopathic interstitial pneumonia
Cause of death
Aged
Retrospective Studies
Aged, 80 and over
Analysis of Variance
business.industry
Interstitial lung disease
General Medicine
respiratory system
Middle Aged
medicine.disease
Neoadjuvant Therapy
respiratory tract diseases
030228 respiratory system
Pulmonary Emphysema
Acute Disease
Disease Progression
Surgery
Female
business
Lung Diseases, Interstitial
Tomography, X-Ray Computed
Subjects
Details
- ISSN :
- 14362813
- Volume :
- 48
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Surgery today
- Accession number :
- edsair.doi.dedup.....09b72dda203212848a2e4df3a068fe65