Glomerular Disease After Kidney Transplantation

Primary and secondary glomerular diseases that cause end-stage kidney disease in native kidneys can also recur in allografts of kidney transplant recipients. While minimal change disease has rarely been reported to recur in the allograft, several other primary glomerular diseases like membranous nephropathy, focal segmental glomerulosclerosis, membranoproliferative glomerulonephritis, and IgA nephropathy tend to recur more commonly. Secondary glomerular diseases like lupus nephritis, diabetic nephropathy, and ANCA-associated vasculitis can also recur in the transplanted kidney. Several of these primary and secondary recurrent diseases can lead to significant allograft failure and loss.