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Highly Branched Gradient Glycopolymer: Enzyme-Assisted Synthesis and Enhanced Bacteria-Binding Ability
- Source :
- Biomacromolecules. 21:5233-5240
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- A one-pot strategy was applied to synchronize enzymatic monomer transformation with reversible addition fragmentation chain transfer (RAFT) polymerization for the synthesis of glycopolymers with highly branched gradient architectures. Also, the linear analogues, block glycopolymers, and gradient glycopolymers were also synthesized for comparison. The binding ability of glycopolymers toward bacteria was then studied by optical density (OD) test, confocal laser scanning microscopy (CLSM), and quartz crystal microbalance with dissipation (QCM-D). The results show that the highly branched gradient glycopolymers have the most remarkable bacteria-binding ability compared with the two linear analogues, gradient glycopolymers, and block glycopolymers. The highly branched glycopolymers were further used as inhibitors in the anti-infection test, demonstrating a significant inhibitory effect on preventing bacteria from infecting the cells.
- Subjects :
- chemistry.chemical_classification
Bacteria
Polymers and Plastics
biology
Polymers
Glycopolymer
Bioengineering
Chain transfer
Quartz crystal microbalance
Polymer
Raft
biology.organism_classification
Polymerization
Biomaterials
chemistry.chemical_compound
Monomer
chemistry
Quartz Crystal Microbalance Techniques
Materials Chemistry
Biophysics
Subjects
Details
- ISSN :
- 15264602 and 15257797
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Biomacromolecules
- Accession number :
- edsair.doi.dedup.....097f9d71cbb3e1531875150a414314de