Back to Search
Start Over
Is Endometrial Scratching Beneficial for Patients Undergoing a Donor-Egg Cycle with or without Previous Implantation Failures? Results of a Post-Hoc Analysis of an RCT
- Source :
- Diagnostics; Volume 11; Issue 7; Pages: 1167, Diagnostics, Diagnostics, Vol 11, Iss 1167, p 1167 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Endometrial scratching (ES) has been proposed as a useful technique to improve outcomes in in vitro fertilization (IVF) cycles, particularly in patients with previous implantation failures. Our objective was to determine if patients undergoing egg-donor IVF cycles had better live birth rates after ES, according to their previous implantation failures. Secondary outcomes were pregnancy rate, clinical pregnancy rate, ongoing pregnancy rate, miscarriage rate, and multiple pregnancy rate. We analysed the results of 352 patients included in the Endoscratch Trial (NCT03108157). A total of 209 were patients with one or no previous implantation failures (105 with an ES done in the previous cycle, group A1, and 104 without ES, group B1), and 143 were patients with at least two previous failed implantations (71 patients with ES, group A2, and 72 without ES, group B2). We found an improvement in pregnancy rates (62.9% in group A1 vs. 55.8% in group B1 vs. 70.4% in group A2 vs. 76.4% in group B2, p = 0.028) in patients with at least two previous implantation failures, but this difference was not statistically different when we compared clinical pregnancy rates (59.1% vs. 51.0% vs. 64.8% vs. 68.1% in groups A1, B1, A2 and B2, respectively, p = 0.104) and live birth rates (52.4% vs. 43.3% vs. 57.8% vs. 55.6% in groups A1, B1, A2 and B2, respectively, p = 0.218). According to these results, we conclude that there is no evidence to recommend ES in egg-donor IVF cycles, regardless of the number of previous failed cycles.
- Subjects :
- Medicine (General)
medicine.medical_specialty
endometrial receptivity
medicine.medical_treatment
Clinical Biochemistry
endometrial scratching
Article
Miscarriage
law.invention
in vitro fertilization
recurrent implantation failure
egg donor IVF cycle
03 medical and health sciences
R5-920
0302 clinical medicine
Randomized controlled trial
law
Post-hoc analysis
medicine
030212 general & internal medicine
Pregnancy
030219 obstetrics & reproductive medicine
In vitro fertilisation
Obstetrics
business.industry
Scratching
medicine.disease
Pregnancy rate
Live birth
business
Subjects
Details
- Language :
- English
- ISSN :
- 20754418
- Database :
- OpenAIRE
- Journal :
- Diagnostics; Volume 11; Issue 7; Pages: 1167
- Accession number :
- edsair.doi.dedup.....09707d033bfd2c1997a99c8929efe1cd
- Full Text :
- https://doi.org/10.3390/diagnostics11071167