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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
- Source :
- Nature Genetics, 48(6), 624-633. Nature Publishing Group, Okbay, A, Baselmans, B M L, de Neve, J E, Turley, P, Nivard, M G, Fontana, M A, Meddens, S F W, Karlsson Linnér, R, Rietveld, C A, Derringer, J, de Vlaming, R, Minica, C C, Hottenga, J J, Vinkhuyzen, A A E, Boomsma, D I, de Geus, E J C, Medland, S E, Meyer, M N, Pickrell, J K, Esko, T, Krueger, R F, Beauchamp, J, Koellinger, P D, Benjamin, D J, Bartels, M & Cesarini, D 2016, ' Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. ', Nature Genetics, vol. 48, no. 6, pp. 624-633 . https://doi.org/10.1038/ng.3552, Okbay, A, Baselmans, B M L, De Neve, J, Turley, P, Nivard, M G, Fontana, M A, Meddens, S F W, Linnér, R K, Rietveld, C A, Derringer, J, Gratten, J, Lees, J, Liu, J Z, De Vlaming, R, Ahluwalia, T S, Buchwald, J, Cavadino, A, Frazier-wood, A C, Furlotte, N A, Garfield, V, Geisel, M H, Gonzalez, J R, Haitjema, S, Karlsson, R, Van Der Laan, S W, Ladwig, K, Lahti, J, Van Der Lee, S J, Lind, P A, Liu, T, Matteson, L, Mihailov, E, Miller, M B, Minica, C C, Nolte, I M, Mook-kanamori, D, Van Der Most, P J, Oldmeadow, C, Qian, Y, Raitakari, O, Rawal, R, Realo, A, Rueedi, R, Schmidt, B, Smith, A V, Stergiakouli, E, Tanaka, T, Taylor, K, Wedenoja, J, Wellmann, J, Westra, H, Willems, S M, Zhao, W, Amin, N, Bakshi, A, Boyle, P A, Cherney, S, Cox, S R, Davies, G, Davis, O S P, Ding, J, Direk, N, Eibich, P, Emeny, R T, Fatemifar, G, Faul, J D, Ferrucci, L, Forstner, A, Gieger, C, Gupta, R, Harris, T B, Harris, J M, Holliday, E G, Hottenga, J, De Jager, P L, Kaakinen, M A, Kajantie, E, Karhunen, V, Kolcic, I, Kumari, M, Launer, L J, Franke, L, Li-gao, R, Koini, M, Loukola, A, Marques-vidal, P, Montgomery, G W, Mosing, M A, Paternoster, L, Pattie, A, Petrovic, K E, Pulkki-råback, L, Quaye, L, Räikkönen, K, Rudan, I, Scott, R J, Smith, J A, Sutin, A R, Trzaskowski, M, Vinkhuyzen, A E, Yu, L, Zabaneh, D, Attia, J R, Bennett, D A, Berger, K, Bertram, L, Boomsma, D I, Snieder, H, Chang, S, Cucca, F, Deary, I J, Van Duijn, C M, Eriksson, J G, Bültmann, U, De Geus, E J C, Groenen, P J F, Gudnason, V, Hansen, T, Hartman, C A, Haworth, C M A, Hayward, C, Heath, A C, Hinds, D A, Hyppönen, E, Iacono, W G, Järvelin, M, Jöckel, K, Kaprio, J, Kardia, S L R, Keltikangas-järvinen, L, Kraft, P, Kubzansky, L D, Lehtimäki, T, Magnusson, P K E, Martin, N G, Mcgue, M, Metspalu, A, Mills, M, De Mutsert, R, Oldehinkel, A J, Pasterkamp, G, Pedersen, N L, Plomin, R, Polasek, O, Power, C, Rich, S S, Rosendaal, F R, Den Ruijter, H M, Schlessinger, D, Schmidt, H, Svento, R, Schmidt, R, Alizadeh, B Z, Sørensen, T I A, Spector, T D, Steptoe, A, Terracciano, A, Thurik, A R, Timpson, N J, Tiemeier, H, Uitterlinden, A G, Vollenweider, P, Wagner, G G, Weir, D R, Yang, J, Conley, D C, Smith, G D, Hofman, A, Johannesson, M, Laibson, D I, Medland, S E, Meyer, M N, Pickrell, J K, Esko, T, Krueger, R F, Beauchamp, J P, Koellinger, P D, Benjamin, D J, Bartels, M & Cesarini, D 2016, ' Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses ', Nature Genetics . https://doi.org/10.1038/ng.3552, Nature Genetics, Nature Genetics, Nature Publishing Group, 2016, 48 (6), pp.624--633. ⟨10.1038/ng.3552⟩, Okbay, A, Baselmans, B M L, De Neve, J-E, Turley, P, Nivard, M G, Fontana, M A, Meddens, S F W, Linnér, R K, Rietveld, C A, Derringer, J, Gratten, J, Lee, J J, Liu, J Z, de Vlaming, R, Ahluwalia, T S, Buchwald, J, Cavadino, A, Frazier-Wood, A C, Furlotte, N A, Garfield, V, Geisel, M H, Gonzalez, J R, Haitjema, S, Karlsson, R, van der Laan, S W, Ladwig, K-H, Lahti, J, van der Lee, S J, Lind, P A, Liu, T, Matteson, L, Mihailov, E, Miller, M B, Minica, C C, Nolte, I M, Mook-Kanamori, D, van der Most, P J, Oldmeadow, C, Qian, Y, Raitakari, O, Rawal, R, Stergiakouli, E, Davis, O S P, Fatemifar, G, Paternoster, L, Haworth, C M A, Sorensen, T, Timpson, N J, Smith, G D, Medland, S E 2016, ' Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses ', Nature Genetics, vol. 48, no. 6, pp. 624-633 . https://doi.org/10.1038/ng.3552, Nature Genetics, 48(6), 624. Nature Publishing Group, Nature Genetics, Nature Publishing Group, 2016, 48 (6), pp.624-633. ⟨10.1038/ng.3552⟩, Nature Genetics, 48(6), 624-636. Nature Publishing Group, Nature Genetics, 48(6), 624, Nature genetics, vol. 48, no. 6, pp. 624-633
- Publication Year :
- 2016
-
Abstract
- Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (vertical bar(p) over cap vertical bar approximate to 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
- Subjects :
- 0301 basic medicine
Netherlands Twin Register (NTR)
Medizin
Genome-wide association study
Disease
Genome-wide association studies
DISEASE
0302 clinical medicine
well-being
neuroticism
Anxiety Disorders/genetics
Bayes Theorem
Depression/genetics
Genome-Wide Association Study
Humans
Phenotype
Polymorphism, Single Nucleotide
Genetics & Heredity
RISK
Genetics
PERSONALITY
[QFIN]Quantitative Finance [q-fin]
Depression
HERITABILITY
COMMON VARIANTS
11 Medical And Health Sciences
Anxiety Disorders
Neuroticism
depression
Behavioural genetics
Life Sciences & Biomedicine
Biology
personality
genetic
epidemiology
ta3111
Article
03 medical and health sciences
SDG 3 - Good Health and Well-being
RESOURCE
Journal Article
Human height
Subjective well-being
behavioural genetics
METAANALYSIS
Genetic association
HAPPINESS
Science & Technology
MAJOR DEPRESSION
06 Biological Sciences
Heritability
030104 developmental biology
genome-wide association studies
HUMAN HEIGHT
030217 neurology & neurosurgery
LifeLines Cohort Study
Developmental Biology
genome-wide analysis
Subjects
Details
- Language :
- English
- ISSN :
- 10614036 and 15461718
- Database :
- OpenAIRE
- Journal :
- Nature Genetics, 48(6), 624-633. Nature Publishing Group, Okbay, A, Baselmans, B M L, de Neve, J E, Turley, P, Nivard, M G, Fontana, M A, Meddens, S F W, Karlsson Linnér, R, Rietveld, C A, Derringer, J, de Vlaming, R, Minica, C C, Hottenga, J J, Vinkhuyzen, A A E, Boomsma, D I, de Geus, E J C, Medland, S E, Meyer, M N, Pickrell, J K, Esko, T, Krueger, R F, Beauchamp, J, Koellinger, P D, Benjamin, D J, Bartels, M & Cesarini, D 2016, ' Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. ', Nature Genetics, vol. 48, no. 6, pp. 624-633 . https://doi.org/10.1038/ng.3552, Okbay, A, Baselmans, B M L, De Neve, J, Turley, P, Nivard, M G, Fontana, M A, Meddens, S F W, Linnér, R K, Rietveld, C A, Derringer, J, Gratten, J, Lees, J, Liu, J Z, De Vlaming, R, Ahluwalia, T S, Buchwald, J, Cavadino, A, Frazier-wood, A C, Furlotte, N A, Garfield, V, Geisel, M H, Gonzalez, J R, Haitjema, S, Karlsson, R, Van Der Laan, S W, Ladwig, K, Lahti, J, Van Der Lee, S J, Lind, P A, Liu, T, Matteson, L, Mihailov, E, Miller, M B, Minica, C C, Nolte, I M, Mook-kanamori, D, Van Der Most, P J, Oldmeadow, C, Qian, Y, Raitakari, O, Rawal, R, Realo, A, Rueedi, R, Schmidt, B, Smith, A V, Stergiakouli, E, Tanaka, T, Taylor, K, Wedenoja, J, Wellmann, J, Westra, H, Willems, S M, Zhao, W, Amin, N, Bakshi, A, Boyle, P A, Cherney, S, Cox, S R, Davies, G, Davis, O S P, Ding, J, Direk, N, Eibich, P, Emeny, R T, Fatemifar, G, Faul, J D, Ferrucci, L, Forstner, A, Gieger, C, Gupta, R, Harris, T B, Harris, J M, Holliday, E G, Hottenga, J, De Jager, P L, Kaakinen, M A, Kajantie, E, Karhunen, V, Kolcic, I, Kumari, M, Launer, L J, Franke, L, Li-gao, R, Koini, M, Loukola, A, Marques-vidal, P, Montgomery, G W, Mosing, M A, Paternoster, L, Pattie, A, Petrovic, K E, Pulkki-råback, L, Quaye, L, Räikkönen, K, Rudan, I, Scott, R J, Smith, J A, Sutin, A R, Trzaskowski, M, Vinkhuyzen, A E, Yu, L, Zabaneh, D, Attia, J R, Bennett, D A, Berger, K, Bertram, L, Boomsma, D I, Snieder, H, Chang, S, Cucca, F, Deary, I J, Van Duijn, C M, Eriksson, J G, Bültmann, U, De Geus, E J C, Groenen, P J F, Gudnason, V, Hansen, T, Hartman, C A, Haworth, C M A, Hayward, C, Heath, A C, Hinds, D A, Hyppönen, E, Iacono, W G, Järvelin, M, Jöckel, K, Kaprio, J, Kardia, S L R, Keltikangas-järvinen, L, Kraft, P, Kubzansky, L D, Lehtimäki, T, Magnusson, P K E, Martin, N G, Mcgue, M, Metspalu, A, Mills, M, De Mutsert, R, Oldehinkel, A J, Pasterkamp, G, Pedersen, N L, Plomin, R, Polasek, O, Power, C, Rich, S S, Rosendaal, F R, Den Ruijter, H M, Schlessinger, D, Schmidt, H, Svento, R, Schmidt, R, Alizadeh, B Z, Sørensen, T I A, Spector, T D, Steptoe, A, Terracciano, A, Thurik, A R, Timpson, N J, Tiemeier, H, Uitterlinden, A G, Vollenweider, P, Wagner, G G, Weir, D R, Yang, J, Conley, D C, Smith, G D, Hofman, A, Johannesson, M, Laibson, D I, Medland, S E, Meyer, M N, Pickrell, J K, Esko, T, Krueger, R F, Beauchamp, J P, Koellinger, P D, Benjamin, D J, Bartels, M & Cesarini, D 2016, ' Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses ', Nature Genetics . https://doi.org/10.1038/ng.3552, Nature Genetics, Nature Genetics, Nature Publishing Group, 2016, 48 (6), pp.624--633. ⟨10.1038/ng.3552⟩, Okbay, A, Baselmans, B M L, De Neve, J-E, Turley, P, Nivard, M G, Fontana, M A, Meddens, S F W, Linnér, R K, Rietveld, C A, Derringer, J, Gratten, J, Lee, J J, Liu, J Z, de Vlaming, R, Ahluwalia, T S, Buchwald, J, Cavadino, A, Frazier-Wood, A C, Furlotte, N A, Garfield, V, Geisel, M H, Gonzalez, J R, Haitjema, S, Karlsson, R, van der Laan, S W, Ladwig, K-H, Lahti, J, van der Lee, S J, Lind, P A, Liu, T, Matteson, L, Mihailov, E, Miller, M B, Minica, C C, Nolte, I M, Mook-Kanamori, D, van der Most, P J, Oldmeadow, C, Qian, Y, Raitakari, O, Rawal, R, Stergiakouli, E, Davis, O S P, Fatemifar, G, Paternoster, L, Haworth, C M A, Sorensen, T, Timpson, N J, Smith, G D, Medland, S E 2016, ' Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses ', Nature Genetics, vol. 48, no. 6, pp. 624-633 . https://doi.org/10.1038/ng.3552, Nature Genetics, 48(6), 624. Nature Publishing Group, Nature Genetics, Nature Publishing Group, 2016, 48 (6), pp.624-633. ⟨10.1038/ng.3552⟩, Nature Genetics, 48(6), 624-636. Nature Publishing Group, Nature Genetics, 48(6), 624, Nature genetics, vol. 48, no. 6, pp. 624-633
- Accession number :
- edsair.doi.dedup.....09631da06060827d38404c7b057deb48
- Full Text :
- https://doi.org/10.1038/ng.3552