Back to Search
Start Over
Biocompatible hybrid silica nanobiocomposites for the efficient delivery of anti-staphylococcal drugs
- Source :
- International Journal of Pharmaceutics. 510:532-542
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- This work reports the non-surfactant templated synthesis and characterization of a new tyrosine—silica/antibiotics (TyR-SiO2/ATBs) nanocomposite, as well as both in vitro and in vivo cytotoxicity and antimicrobial activity against the microbial pathogen Staphylococcus aureus. The in vitro microbiological tests proved that the obtained nanobiostructure significantly enhance the antimicrobial activity of three commonly used antibiotics against S. aureus (i.e. erythromycin (ERI), gentamicin (GEN), and cloxacillin (CLO)) as revealed by the increased diameters of the growth inhibition zones and the decreased minimal inhibitory concentration values, as well as by the inhibitory effect of sub-lethal antibiotic concentrations on the ability of the respective pathogenic strains to adhere and colonize different substrata. These results, correlated with the lack of toxicity against mesenchymal stem cells along with an appropriate in vivo biodistribution highlight the promising therapeutic potential of this carrier that allows a decrease of the required active doses while significantly lessening the harmful side effects of the medication on the host organism.
- Subjects :
- Staphylococcus aureus
medicine.drug_class
Antibiotics
Pharmaceutical Science
Biocompatible Materials
Microbial Sensitivity Tests
02 engineering and technology
010402 general chemistry
medicine.disease_cause
01 natural sciences
Microbiology
Mice
Minimum inhibitory concentration
Cloxacillin
Animals
Humans
Medicine
Tissue Distribution
Cells, Cultured
Mice, Inbred BALB C
business.industry
Mesenchymal Stem Cells
Staphylococcal Infections
Silicon Dioxide
021001 nanoscience & nanotechnology
Antimicrobial
In vitro
Anti-Bacterial Agents
0104 chemical sciences
Toxicity
Gentamicin
0210 nano-technology
business
medicine.drug
Subjects
Details
- ISSN :
- 03785173
- Volume :
- 510
- Database :
- OpenAIRE
- Journal :
- International Journal of Pharmaceutics
- Accession number :
- edsair.doi.dedup.....094d71caf1892b3c9f93354351afff07