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Responsive Hydrogel Microcarrier‐Integrated Microneedles for Versatile and Controllable Drug Delivery
- Source :
- Advanced Healthcare Materials. 10:2002249
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Stratagems of drug delivery are important for disease treatment and other biomedical areas. In this study, a novel stratagem is presented for versatile and controllable drug delivery by integrating photoresponsive drug delivery microspheres (PDDMs) into pyramid microneedle (MN) arrays. The PDDMs, containing black-phosphorus (BP) and poly (N-isopropylacrylamide) (pNIPAM), are generated by a flexible capillary microfluidic method. Benefiting from the high water content of the pNIPAM hydrogel, various bioactive substances can be loaded and maintain biological activity. Furthermore, due to the near-infrared (NIR) absorption and conversion capabilities of the contained BP, the PDDMs can increase temperature, shrink volume, and release their encapsulated bioactives under the trigger of biocompatible NIR. In addition, as the PDDMs are stuffed into the solid MN arrays of porous ethoxylated trimethylolpropane triacrylate (ETPTA), the composited PDDMs-MNs system has enough mechanical strength to penetrate into the skin and can deliver drugs underneath the skin uniformly. Based on the resultant PDDMs-MNs, it is demonstrated that insulin can be controllably released to adjust blood glucose levels of streptozotocin (STZ)-induced diabetic mice. Thus, it is believed that the PDDMs-MNs can act as an excellent drugs delivery system and will find many practical values in clinical medicine.
- Subjects :
- Materials science
Microfluidics
Biomedical Engineering
Pharmaceutical Science
Nanotechnology
02 engineering and technology
Absorption (skin)
Administration, Cutaneous
010402 general chemistry
01 natural sciences
Diabetes Mellitus, Experimental
Microsphere
Biomaterials
Mice
Drug Delivery Systems
Animals
food and beverages
Microcarrier
Hydrogels
Diabetic mouse
021001 nanoscience & nanotechnology
Biocompatible material
0104 chemical sciences
Increase temperature
Needles
Drug delivery
0210 nano-technology
Subjects
Details
- ISSN :
- 21922659 and 21922640
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Advanced Healthcare Materials
- Accession number :
- edsair.doi.dedup.....0940933b95ee9aad5e917cb54381666b