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Menopause Is Associated With Endothelial Dysfunction in Women
- Source :
- Scopus-Elsevier
- Publication Year :
- 1996
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1996.
-
Abstract
- To evaluate the effect of endogenous estrogens on endothelial function in humans, we examined whether menopause is associated with impairment in endothelium-dependent vasodilation in normotensive and essential hypertensive women. In 73 normotensive subjects (37 women, 36 men) and 73 hypertensive patients (36 women, 37 men), we studied endothelial function by measuring forearm blood flow modifications (strain-gauge plethysmography) induced by intrabrachial acetylcholine (0.15, 0.45, 1.5, 4.5, and 15 μg/100 mL per minute), an endothelium-dependent vasodilator, and sodium nitroprusside (1, 2, and 4 μg/100 mL per minute), an endothelium-independent vasodilator. Women younger than 45 years had normal menstrual cycles. In essential hypertensive patients, responses to acetylcholine but not to sodium nitroprusside were significantly ( P r =−.88, P r =−.87, P r =−.46, P r =−.48, P
- Subjects :
- Adult
Male
Nitroprusside
medicine.medical_specialty
Adolescent
Endothelium
medicine.drug_class
Hemodynamics
Endogeny
Vasodilation
Internal medicine
Internal Medicine
medicine
Humans
Endothelial dysfunction
Aged
business.industry
Estrogens
Middle Aged
medicine.disease
Acetylcholine
Endothelial stem cell
Menopause
medicine.anatomical_structure
Endocrinology
Estrogen
Hypertension
Female
Endothelium, Vascular
business
Subjects
Details
- ISSN :
- 15244563 and 0194911X
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Hypertension
- Accession number :
- edsair.doi.dedup.....0935daabfab42746baf5896cad380a89