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Different responses elicited in vitro by antibodies to IgM and IgD in cells from a surface IgM + D-positive human follicular lymphoma
- Source :
- Scandinavian journal of immunology. 17(2)
- Publication Year :
- 1983
-
Abstract
- The effect of anti-Igs in combination with the tumour promotor TPA on DNA and Ig synthesis in a human follicular germinal centre cell lymphoma carrying sIgM and sIgD was investigated. The lymphoma cells responded to both anti-mu and anti-delta chains and to anti-lambda light chains by DNA synthesis, as measured by methyl-(3H)-thymidine incorporation. Flow cytofluorometric measurements, however, showed that only anti-mu chains induced marked increase in cytoplasmic Ig content. This result suggests that in certain B-cell subsets the signals elicited via sIgM and sIgD are different.
- Subjects :
- biology
DNA synthesis
Immunology
Follicular lymphoma
Receptors, Antigen, B-Cell
Promoter
General Medicine
DNA
Immunoglobulin D
medicine.disease
Immunoglobulin light chain
Molecular biology
In vitro
Lymphoma
Antibodies, Anti-Idiotypic
Myeloma Proteins
Phenotype
Immunoglobulin M
biology.protein
medicine
Humans
Tetradecanoylphorbol Acetate
Antibody
Lymphoma, Follicular
Subjects
Details
- ISSN :
- 03009475
- Volume :
- 17
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Scandinavian journal of immunology
- Accession number :
- edsair.doi.dedup.....092e9bb1246276d3e8fcf569fcc51fb2