Garcinone C Suppresses Tumorsphere Formation and Invasiveness by Hedgehog/Gli1 Signaling in Colorectal Cancer Stem-like Cells

Authors :: Yimeng Zhou
Shuai Qiu
Jin Tae Kim
Seung Beom Lee
Ho Jin Park
Moon Jeong Son
Hong Jin Lee
Jing Chen
Source :: Journal of Agricultural and Food Chemistry. 70:7941-7952
Publication Year :: 2022
Publisher :: American Chemical Society (ACS), 2022.
Abstract: Hyperactivation of hedgehog signaling occurs in colorectal cancer stem-like cells (CSCs), a rare subpopulation, potentially involved in metastasis, chemotherapy resistance, and cancer relapse. Garcinone C, a xanthone isolated from mangosteen (

Subjects :: Recurrence
Cell Line, Tumor
Xanthones
Neoplastic Stem Cells
Humans
Hedgehog Proteins
General Chemistry
Colorectal Neoplasms
General Agricultural and Biological Sciences
Zinc Finger Protein GLI1
Cell Proliferation

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