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Effects of lipophilicity and functional groups of synthetic cannabinoids on their blood concentrations and urinary excretion
- Source :
- Forensic science international. 307
- Publication Year :
- 2019
-
Abstract
- The influence of lipophilicity and functional groups of synthetic cannabinoids (SCs) on their blood concentrations and urinary excretion has been studied by analyzing blood and urine specimens sampled from drivers who were involved in a car crashes under the influence of SCs. A total of 58 specimens (26 urine and 31 blood specimens), sampled within 13h of the occurrence, were analyzed by liquid chromatography-tandem mass spectrometry. Fifteen SCs were detected in those specimens; the SCs detected were categorized as follows: Class 1, Naphthoyl/Benzoyl indole (EAM2201 and three other analogs); Class 2, Indole-3-carboxylate/carboxamide containing naphthol/quinol (5F-PB-22 and four other analogs); and Class 3, Indazole-3-carboxamide containing valine/tert-leucine derivative (5F-AMB and five other analogs). The calculated lipophilicity index log P, the octanol/water participation coefficient, of those SCs in Classes 1, 2, and 3 ranged between 5.01-8.14, 5.80-6.74 and 2.29-3.81, respectively. Class 3 SCs were detectable in 12 out of 13 urine specimens, but those in Classes 1 and 2 were not detected in urine. Our analytical results indicated that the boundary line for their detectability in urine lies between log P 4 and 5. The blood concentrations of Class 3 SCs varied widely (0.0036-31ng/ml) depending on their log P, while much smaller variation was observed among those in Class 2 (0.10-5.0ng/ml).
- Subjects :
- Octanol
Octanols
Chromatography
medicine.drug_class
Cannabinoids
Water
Carboxamide
Urine
Pathology and Forensic Medicine
Partition coefficient
chemistry.chemical_compound
Pharmacokinetics
chemistry
Valine
Tandem Mass Spectrometry
Lipophilicity
Synthetic cannabinoids
medicine
Humans
Law
medicine.drug
Chromatography, Liquid
Subjects
Details
- ISSN :
- 18726283
- Volume :
- 307
- Database :
- OpenAIRE
- Journal :
- Forensic science international
- Accession number :
- edsair.doi.dedup.....09273e2be41747d54573c39e35a346fe