Additional file 1: of Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

Calculations of AUC and iAUC. Information on how AUC and iAUC was calculated in the cohorts. Table S1: Participant characteristics in the ADDITION-PRO cohort and Inter99. Anthropometric measures of individuals in the ADDITION-PRO and Inter99 cohort. Table S2. Association of variants (rs36210421 and rs1805123) with QT interval and with metabolic and incretin levels in the Inter99 cohort (n = 5487). Table with measures of QTcF interval and glucose levels in the Inter99 cohort sorted by genetic variant and combined in a genetic risk score. Table S3. Association of KCNH2 variant rs36210421 with metabolic and incretin levels in ADDITION-PRO cohort (N = 1324) (Non diabetes and newly diagnosed T2D). Table with measures of glucose, insulin GIP, GLP-1 and glucagon levels according to carrier status for rs1805123 and rs36210421. Figure S1. Levels of incretins and glucagon according to number of risk alleles. Levels of GLP-1, GIP and Glucagon during an OGTT according to number of risk alleles in the GRS. (DOCX 122 kb)