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Efficacy and tolerability of tolterodine extended-release in continent patients with overactive bladder and nocturia
- Source :
- BJU International. 97:1262-1266
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- OBJECTIVE To evaluate the clinical efficacy and tolerability of tolterodine extended-release (ER) in continent patients with overactive bladder (OAB) and nocturia. PATIENTS AND METHODS A post hoc analysis was conducted of data from a 12-week, double-blind study of 850 patients randomized to tolterodine ER (4 mg once daily) or placebo, taken within 4 h of going to bed. Patients with a mean of ≥ 8 voids/24 h were enrolled, including a mean of ≥ 2.5 voids/night. Patients completed 7-day voiding diaries, and for each void an urgency rating was assessed using a 5-point scale (1, none; 5, urgency incontinence); 24-h voids were categorized by urgency rating: total (1–5), non-OAB (1–2), OAB (3–4), and severe OAB (4–5) voids. All adverse events were recorded. RESULTS The post hoc analysis included 513 patients (243 placebo; 270 tolterodine ER; 58% men) who were continent at baseline; 47% of 24-h voids were classed as non-OAB, and 12% as severe OAB. After 12 weeks of treatment, tolterodine ER significantly reduced mean urgency rating and 24-h OAB, severe OAB, and total voids vs placebo. Tolterodine ER did not affect normal, non-OAB voids, and there were no significant adverse events related to voiding. Other than dry mouth (tolterodine ER, 9% vs placebo, 2%), all the adverse events were reported in
- Subjects :
- Adult
Male
medicine.medical_specialty
Tolterodine Tartrate
Urology
Phenylpropanolamine
Muscarinic Antagonists
urologic and male genital diseases
Placebo
Xerostomia
Cresols
Double-Blind Method
Post-hoc analysis
medicine
Humans
Nocturia
Benzhydryl Compounds
Adverse effect
Aged
Aged, 80 and over
business.industry
Middle Aged
Urination Disorders
medicine.disease
humanities
female genital diseases and pregnancy complications
Urodynamics
Treatment Outcome
Tolerability
Overactive bladder
Delayed-Action Preparations
Female
Tolterodine
medicine.symptom
Complication
business
Constipation
medicine.drug
Subjects
Details
- ISSN :
- 1464410X and 14644096
- Volume :
- 97
- Database :
- OpenAIRE
- Journal :
- BJU International
- Accession number :
- edsair.doi.dedup.....08f775b0071ca85e65da9a893ca4d02e