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Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells
- Source :
- BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018), BMC Cancer, BMC Cancer, 18(1). BioMed Central, BMC cancer, 18 (1
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Vascular supply of tumors is one of the main targets for cancer therapy. Here, we investigated if plocabulin (PM060184), a novel marine-derived microtubule-binding agent, presents antiangiogenic and vascular-disrupting activities.<br />info:eu-repo/semantics/published
- Subjects :
- Physiologic/drug effects
0301 basic medicine
Cancer Research
Polyketides/metabolism
Angiogenesis
Endothelial cells
Nude
Cell Movement/drug effects
Human Umbilical Vein Endothelial Cells/drug effects
Plasma protein binding
Microtubules
Mice
0302 clinical medicine
Cell Movement
Tubulin
Neoplasms
Microtubules -- drug effects -- metabolism
Plocabulin (PM060184)
Neovascularization, Pathologic -- prevention & control
Tubulin -- metabolism
Tumor
Neovascularization, Pathologic
Chemistry
Polyketides -- metabolism -- pharmacology
Neovascularization, Physiologic/drug effects
Tubulin inhibitors
Sciences bio-médicales et agricoles
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Pyrones -- metabolism -- pharmacology
Cell biology
Tumor Burden
Human Umbilical Vein Endothelial Cells -- drug effects -- metabolism -- physiology
Endothelial stem cell
Neovascularization, Pathologic/prevention & control
Oncology
Tubulin Binding Agent
030220 oncology & carcinogenesis
Cancer treatment
Neovascularization, Physiologic -- drug effects
Vascular-disrupting agents
Female
Pathologic/prevention & control
Tumor Burden/drug effects
Research Article
Protein Binding
Angiogenesis inhibitors
Mice, Nude
Neovascularization, Physiologic
lcsh:RC254-282
Neoplasms/blood supply
Cell Line
03 medical and health sciences
Microtubule
In vivo
Cell Line, Tumor
Genetics
Human Umbilical Vein Endothelial Cells
Animals
Humans
Neoplasms -- blood supply -- drug therapy -- pathology
Neovascularization
Cell Movement -- drug effects
Pyrones/metabolism
Tubulin/metabolism
Xenograft Model Antitumor Assays
In vitro
030104 developmental biology
Cell culture
Pyrones
Polyketides
Microtubules/drug effects
Tumor Burden -- drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....08f467481f65bafbc70105e2a89bcdca
- Full Text :
- https://doi.org/10.1186/s12885-018-4086-2