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The Influence of Polymer Composition on the Hydrolytic and Enzymatic Degradation of Polyesters and Their Block Copolymers with PDMAEMA
- Source :
- Materials, Vol 14, Iss 3636, p 3636 (2021), Materials, Volume 14, Issue 13
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Well-defined, semi-degradable polyester/polymethacrylate block copolymers, based on ε-caprolactone (CL), d,l-lactide (DLLA), glycolide (GA) and N,N′-dimethylaminoethyl methacrylate (DMAEMA), were synthesized by ring-opening polymerization (ROP) and atom transfer radical polymerization. Comprehensive degradation studies of poly(ε-caprolactone)-block-poly(N,N′-dimethylaminoethyl methacrylate) (PCL-b-PDMAEMA) on hydrolytic degradation and enzymatic degradation were performed, and those results were compared with the corresponding aliphatic polyester (PCL). The solution pH did not affect the hydrolytic degradation rate of PCL (a 3% Mn loss after six weeks). The presence of a PDMAEMA component in the copolymer chain increased the hydrolysis rates and depended on the solution pH, as PCL-b-PDMAEMA degraded faster in an acidic environment (36% Mn loss determined) than in a slightly alkaline environment (27% Mn loss). Enzymatic degradation of PCL-b-PDMAEMA, poly(d,l-lactide)-block-poly(N,N′-dimethylaminoethyl methacrylate) (PLA-b-PDMAEMA) and poly(lactide-co-glycolide-co-ε-caprolactone)-block-poly(N,N′-dimethylaminoethyl methacrylate) (PLGC-b-PDMAEMA) and the corresponding aliphatic polyesters (PCL, PLA and PLGC) was performed by Novozyme 435. In enzymatic degradation, PLGC degraded almost completely after eleven days. For polyester-b-PDMAEMA copolymers, enzymatic degradation primarily involved the ester bonds in PDMAEMA side chains, and the rate of polyester degradation decreased with the increase in the chain length of PDMAEMA. Amphiphilic copolymers might be used for biomaterials with long-term or midterm applications such as nanoscale drug delivery systems with tunable degradation kinetics.
- Subjects :
- PDMAEMA
Technology
02 engineering and technology
010402 general chemistry
Methacrylate
01 natural sciences
Article
Hydrolysis
Polymer chemistry
Side chain
Copolymer
enzymatic degradation
(bio)degradable polyesters
General Materials Science
hydrolytic degradation
Microscopy
QC120-168.85
Atom-transfer radical-polymerization
Chemistry
QH201-278.5
021001 nanoscience & nanotechnology
Engineering (General). Civil engineering (General)
0104 chemical sciences
TK1-9971
Polyester
block copolymers
Polymerization
Descriptive and experimental mechanics
Degradation (geology)
Electrical engineering. Electronics. Nuclear engineering
TA1-2040
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 19961944
- Volume :
- 14
- Issue :
- 3636
- Database :
- OpenAIRE
- Journal :
- Materials
- Accession number :
- edsair.doi.dedup.....08ef7afebcaad41e52d7c5cae53eb732