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Liver-transplant-free survival according to alkaline phosphatase and GLOBE score in patients with primary biliary cholangitis treated with ursodeoxycholic acid
- Source :
- Alimentary Pharmacology & Therapeutics, 56(9), 1408-1418. Wiley-Blackwell Publishing Ltd, Alimentary Pharmacology and Therapeutics, 56(9), 1408-1418. Wiley-Blackwell, ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Publication Year :
- 2022
- Publisher :
- WILEY, 2022.
-
Abstract
- BACKGROUND: After 1 year of ursodeoxycholic acid (UDCA), patients with primary biliary cholangitis (PBC) may have a normal GLOBE score despite high alkaline phosphatase (ALP) levels. AIM: To assess the association between ALP and liver transplantation (LT)-free survival according to the GLOBE score METHODS: Among patients with a normal or elevated GLOBE score in the Global PBC cohort, the association between ALP after 1 year of UDCA and the risk of LT/death was assessed. The LT-free survival was compared with that of a matched general population. RESULTS: After 1 year of UDCA, ALP was associated with the risk of LT/death (aHR 1.31, 95% CI 1.003-1.72, p = 0.048) among 2729 patients with a normal GLOBE score. The 10-year LT-free survival among these patients with an ALP >2.0 × ULN was 94.0% (95% CI 90.1-97.9) for those
Details
- Language :
- English
- ISSN :
- 02692813 and 13652036
- Database :
- OpenAIRE
- Journal :
- Alimentary Pharmacology & Therapeutics, 56(9), 1408-1418. Wiley-Blackwell Publishing Ltd, Alimentary Pharmacology and Therapeutics, 56(9), 1408-1418. Wiley-Blackwell, ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Accession number :
- edsair.doi.dedup.....08e21db87bed0bed82e24c29d9491dfb