The large dense core vesicle: a normal organelle of the central nervous system myelinated axon

Large dense core vesicles (LDCV) were found frequently enough in normal guinea pig central white matter, basis pontis and spinal cord posterior columns to be regarded as a normal organelle. A review of studies of LDCV and dense core particles (DCP), which have a different cytological localization and appear to be associated with a variety of diseases, suggests that they are the same, and hence remarkably ubiquitous. LDCV should no longer be regarded as a type of synaptic vesicle, but as an incompletely defined organelle common to many cell types.