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Dance with the Devil: Stress Granules and Signaling in Antiviral Responses
- Source :
- Viruses, Vol 12, Iss 984, p 984 (2020), Viruses
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Cells have evolved highly specialized sentinels that detect viral infection and elicit an antiviral response. Among these, the stress-sensing protein kinase R, which is activated by double-stranded RNA, mediates suppression of the host translation machinery as a strategy to limit viral replication. Non-translating mRNAs rapidly condensate by phase separation into cytosolic stress granules, together with numerous RNA-binding proteins and components of signal transduction pathways. Growing evidence suggests that the integrated stress response, and stress granules in particular, contribute to antiviral defense. This review summarizes the current understanding of how stress and innate immune signaling act in concert to mount an effective response against virus infection, with a particular focus on the potential role of stress granules in the coordination of antiviral signaling cascades.
- Subjects :
- G3BP1
0301 basic medicine
stress granules
lcsh:QR1-502
antiviral signaling
Review
virus
Biology
Cytoplasmic Granules
Virus Replication
lcsh:Microbiology
Virus
03 medical and health sciences
Stress granule
Virology
Animals
Humans
Integrated stress response
Innate immune system
030102 biochemistry & molecular biology
Translation (biology)
stress response
PKR
Protein kinase R
Cell biology
030104 developmental biology
Infectious Diseases
Viral replication
Virus Diseases
Viruses
innate immune response
Signal transduction
Virus Physiological Phenomena
Subjects
Details
- ISSN :
- 19994915
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Viruses
- Accession number :
- edsair.doi.dedup.....08df9df5dae6dcd202ba3e75e22f9e7e