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Antisynthetase antibody syndrome: case report and review of the literature
- Source :
- Clinical rheumatology. 32(5)
- Publication Year :
- 2013
-
Abstract
- Antisynthetase antibody syndrome is a rare autoimmune disease that may present with variable systemic manifestations, mainly polymyositis, interstitial lung disease, skin lesions, and Raynaud’s phenomenon. This diagnosis should always come to mind in patients that present with signs of myositis, dermatomyositis, or polymyositis associated with interstitial lung disease. On the following paper, we report the case of a 52-year-old man who presented with a 2-month history of asymmetric polyarthralgia, myalgia, weight loss of 8 kg, and progressive muscle weakness associated with dyspnea, orthopnea, and dysphonia. Further tests revealed myositis, interstitial pneumonia, and elevation of anti-Jo-1 antibodies. A diagnosis of antisynthetase antibody syndrome was made and the patient showed good response to treatment with corticoids and methotrexate. Finally, we present a short review of the literature.
- Subjects :
- myalgia
Male
Pathology
medicine.medical_specialty
Orthopnea
Biopsy
Polymyositis
Rheumatology
Internal medicine
Weight Loss
medicine
Humans
Myositis
Autoimmune disease
Muscle Weakness
business.industry
Muscles
Interstitial lung disease
General Medicine
Myalgia
Dermatomyositis
Middle Aged
medicine.disease
Dermatology
Arthralgia
Treatment Outcome
Antibodies, Antinuclear
medicine.symptom
business
Lung Diseases, Interstitial
Tomography, X-Ray Computed
Subjects
Details
- ISSN :
- 14349949
- Volume :
- 32
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Clinical rheumatology
- Accession number :
- edsair.doi.dedup.....08dcf01b1fc0a3a21777776fff09024f